… This phenomenon has been shown for several neuroreceptor ligands in which
displacement of the radioligand occurs far more rapidly than could be attributed to the slow k 4 …

Molecular imaging, the study of receptors, transporters and enzymes, as well as other cellular
processes, has grown in recent years to be one of the most active neuroimaging areas. …

The classical dopamine hypothesis of schizophrenia postulates a hyperactivity of
dopaminergic transmission at the D 2 receptor. We measured in vivo occupancy of striatal D 2 …

This chapter is an update on the dopamine (DA) imbalance in schizophrenia, including the
evidence for subcortical hyperstimulation of D2 receptors underlying positive symptoms and …

Long-term sensitization is a process whereby exposure to a given stimulus such as a drug
or a stressor results in an enhanced response at subsequent exposures. Sensitization of …

The dopamine hypothesis of schizophrenia proposes that hyperactivity of dopaminergic
transmission is associated with this illness, but direct observation of abnormalities of dopamine …

Several groups have provided evidence that positron emission tomography (PET) and
single-photon emission computed tomography (SPECT) neuroreceptor imaging techniques might …

OBJECTIVE: The authors previously observed an increase in striatal dopamine transmission
following amphetamine challenge in 15 untreated patients with schizophrenia compared to …

Studies in nonhuman primates documented that appropriate stimulation of dopamine (DA)
D 1 receptors in the dorsolateral prefrontal cortex (DLPFC) is critical for working memory …

Background: Abnormalities of dopamine function in schizophrenia are suggested by the
common antidopaminergic properties of antipsychotic medications. However, direct evidence of …