Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
The administration of leptin 1 to leptin-deficient humans, and the analogous Lep ob /Lep ob
mice, effectively reduces hyperphagia and obesity 2 , 3 . But common obesity is associated …
mice, effectively reduces hyperphagia and obesity 2 , 3 . But common obesity is associated …
[HTML][HTML] Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine
The human dopamine D4 receptor (D4R) has received considerable attention because of its
high affinity for the atypical antipsychotic clozapine and the unusually polymorphic nature of …
high affinity for the atypical antipsychotic clozapine and the unusually polymorphic nature of …
Activation of central melanocortin pathways by fenfluramine
D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective
weight loss drugs, but was withdrawn from clinical use because of reports of cardiac …
weight loss drugs, but was withdrawn from clinical use because of reports of cardiac …
Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations
MA Kelly, M Rubinstein, TJ Phillips… - Journal of …, 1998 - Soc Neuroscience
Locomotor activity is a polygenic trait that varies widely among inbred strains of mice ( Flint et
al., 1995 ). To characterize the role of D2 dopamine receptors in locomotion, we generated …
al., 1995 ). To characterize the role of D2 dopamine receptors in locomotion, we generated …
Routing metrics and protocols for wireless mesh networks
…, DCM Saade, MG Rubinstein - IEEE …, 2008 - ieeexplore.ieee.org
WMNs are low-cost access networks built on cooperative routing over a backbone composed
of stationary wireless routers. WMNs must deal with the highly unstable wireless medium. …
of stationary wireless routers. WMNs must deal with the highly unstable wireless medium. …
[HTML][HTML] Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice
Dopamine secreted from hypophysial hypothalamic neurons is a principal inhibitory regulator
of pituitary hormone secretion. Mice with a disrupted D2 dopamine receptor gene had …
of pituitary hormone secretion. Mice with a disrupted D2 dopamine receptor gene had …
Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors
Dopamine (DA) D 2 receptors expressed in DA neurons (D 2 autoreceptors) exert a negative
feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D 2 …
feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D 2 …
Hypothalamic Proopiomelanocortin Neurons Are Glucose Responsive and Express KATP Channels
Hypothalamic proopiomelanocortin (POMC) neurons are critical for controlling homeostatic
functions in the mammal. We used a transgenic mouse model in which the POMC neurons …
functions in the mammal. We used a transgenic mouse model in which the POMC neurons …
Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis.
M Rubinstein, JS Mogil, M Japón… - Proceedings of the …, 1996 - National Acad Sciences
A physiological role for beta-endorphin in endogenous pain inhibition was investigated by
targeted mutagenesis of the proopiomelanocortin gene in mouse embryonic stem cells. The …
targeted mutagenesis of the proopiomelanocortin gene in mouse embryonic stem cells. The …
In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development.
MA Japón, M Rubinstein… - Journal of Histochemistry …, 1994 - journals.sagepub.com
We used 35S-labeled oligonucleotides and cRNAs (riboprobes) to detect the temporal order
and spatial pattern of anterior pituitary hormone gene expression in (B6CBF1 x B6CBF1)F2 …
and spatial pattern of anterior pituitary hormone gene expression in (B6CBF1 x B6CBF1)F2 …