Wnt signaling function starts during the development of the nervous system and is crucial for
synaptic plasticity in the adult brain. Clearly Wnt effects in synaptic and plastic processes …

10.7554/eLife.20362.001 Interneurons are critical for proper neural network function and
can activate Ca 2+ signaling in astrocytes. However, the impact of the interneuron-astrocyte …

The role of the Wnt signaling pathway during synaptic development has been well established.
In the adult brain, different components of Wnt signaling are expressed, but little is known …

Background Soluble amyloid-β (Aβ;) oligomers have been recognized to be early and key
intermediates in Alzheimer's disease (AD)-related synaptic dysfunction. Aβ oligomers block …

GABA A receptors (GABA A -Rs) play a significant role in mediating fast synaptic inhibition
and it is the main inhibitory receptor in the CNS. The role of Wnt signaling in coordinating …

Astrocytes exhibit spontaneous calcium oscillations that could induce the release of
glutamate as gliotransmitter in rat hippocampal slices. However, it is unknown whether this …

The Dlg4 gene encodes for post-synaptic density protein 95 (PSD95), a major synaptic protein
that clusters glutamate receptors and is critical for plasticity. PSD95 levels are diminished …

Synaptic plasticity is the capacity generated by experience to modify the neural function and,
thereby, adapt our behaviour. Long-term plasticity of glutamatergic and GABAergic …

The threshold for bidirectional modification of synaptic plasticity is known to be controlled by
several factors, including the balance between protein phosphorylation and …

Learning the location of relevant places in the environment is crucial for survival. Such capacity
is supported by a distributed network comprising the prefrontal cortex and hippocampus, …