Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Objective Studies of major depression in twins and families have shown moderate to high
heritability, but extensive molecular studies have failed to identify susceptibility genes …

Importance Most previous genome-wide association studies (GWAS) of depression have used
data from individuals of European descent. This limits the understanding of the underlying …

Adversity, particularly in early life, can cause illness. Clues to the responsible mechanisms
may lie with the discovery of molecular signatures of stress, some of which include alterations …

Background Major depressive disorder (MDD) is a disabling mood disorder, and despite a
known heritable component, a large meta-analysis of genome-wide association studies …

Over the past 5 years, the genome-wide association study (GWAS) method has produced
significant findings that are providing insights into the biological pathways involved in disease …

Importance The association between major depressive disorder (MDD) and obesity may
stem from shared immunometabolic mechanisms particularly evident in MDD with atypical …

BackgroundIndividuals with a mental health disorder appear to be at increased risk of medical
illness.AimsTo examine rates of medical illnesses in patients with bipolar disorder (n = …

Epidemiological studies have recognized a genetic diathesis for suicidal behavior, which is
independent of other psychiatric disorders. Genome‐wide association studies (GWAS) on …

Schizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions
encountered in medical practice. A recent landmark SCZ study of the protein-coding regions …