In the research field of psychoneuroimmunology, accumulating evidence has indicated the
existence of reciprocal communication pathways between nervous, endocrine and immune …

Studies show that administration of interferon (IFN)-α causes a significant increase in
depressive symptoms. The enzyme indoleamine 2, 3-dioxygenase (IDO), which converts …

The mechanisms by which administration of interferon-α induces neuropsychiatric side
effects, such as depressive symptoms and changes in cognitive function, are not clear as yet. …

Objective: The negative affective response to daily life stressors, which previous work suggest
is a fundamental depression endophenotype, may be moderated by positive emotions. It …

OBJECTIVE: Proinflammatory cytokines have the potential to activate the hypothalamo-pituitary-adrenocortical
(HPA) axis, and HPA axis hyperactivity is also encountered in depression…

Background Electronic diaries are increasingly used in diverse disciplines to collect
momentary data on experienced feelings, cognitions, behavior and social context in real life …

BACKGROUND: Major depression has been associated cross-sectionally with increased
cell-mediated immune activation but causality has been difficult to establish. This study …

Objective: To examine, using a cross-twin cross-trait design, the hypotheses 1) that the
genetic and environmental susceptibility to depression is expressed, in part, as alterations in …

AIM: To study the predictive value of the vegetative-depressive symptoms of the Zung
Depression Rating Scale for the occurrence of depression during treatment with peg-interferon α-…

lation is associated with antidepressant effects. 1-5 Interestingly enough, the 2 studies
investigating relatively older depressed patients2, 5 demonstrated a lesser effect than did the …