The pacemaker role of the suprachiasmatic nucleus in a mammalian circadian system was
tested by neural transplantation by using a mutant strain of hamster that shows a short …

The tau mutation is a semidominant autosomal allele that dramatically shortens period
length of circadian rhythms in Syrian hamsters. We report the molecular identification of the …

A mutation has been found that dramatically shortens the period of the circadian locomotor
rhythm of golden hamsters. The pattern of inheritance of this mutation suggests that it …

Sleep deprivation, shift work, and jet lag all disrupt normal biological rhythms and have major
impacts on health; however, circadian disorganization has never been shown as a causal …

While functional roles for biological clocks have been demonstrated in organisms throughout
phylogeny, the adaptive advantages of circadian organization per se are largely matters of …

Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We
report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, …

Day/night rhythms are recognized as important to normal cardiovascular physiology and
timing of adverse cardiovascular events; however, their significance in disease has not been …

Photic signals affect circadian activity rhythms by both phasic and tonic mechanisms that
modulate pacemaker phase and period. In mammals, the effects of light on circadian activity are …

It is thought that circadian rhythms may influence learning and memory processes. However,
research supporting this view does not dissociate a mnemonic impairment from other …

Bipolar disorder is a debilitating psychopathology with unknown etiology. Accumulating
evidence suggests the possible involvement of Na + ,K + -ATPase dysfunction in the …