The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

mGluR1 mutant mice are viable but show characterlstic cerebellar symptoms such as ataxlc
galt and lntentlon tremor. The anatomy of the cerebellum Is not overtly dlsturbed. Excitatory …

Optogenetics has revolutionized the experimental interrogation of neural circuits and holds
promise for the treatment of neurological disorders. It is limited, however, because visible …

Endogenous cannabinoids are considered to function as diffusible and short-lived modulators
that may transmit signals retrogradely from postsynaptic to presynaptic neurons. To …

We report a type of synaptic modulation that involves retrograde signaling from postsynaptic
metabotropic glutamate receptors (mGluRs) to presynaptic cannabinoid receptors. …

In rabbit cerebellar cortex, local stimulation of parallel fibers induced field potentials with two
negative peaks, n 1 representing conducting spikes of parallel fibers and n 2 postsynaptic …

Endocannabinoids work as retrograde messengers and contribute to short-term and long-term
modulation of synaptic transmission via presynaptic cannabinoid receptors. It is generally …

Endocannabinoids are released from postsynaptic neurons and cause retrograde suppression
of synaptic transmission. Anandamide and 2-arachidonoylglycerol (2-AG) are regarded …

To study the function of GLAST, a glutamate transporter highly expressed in the cerebellar
Bergmann astrocytes, the mouse GLAST gene was inactivated. GLAST‐deficient mice …

Targeted deletion of metabotropic glutamate receptor–subtype 1 (mGluR1) gene can cause
defects in development and function in the cerebellum. We introduced the mGluR1α …