The brain is the central organ involved in perceiving and adapting to social and physical
stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to …

The central endocannabinoid system is a neuroactive lipid signalling system in the brain
which acts to control neurotransmitter release. The expression patterns of this system …

Stress affects a constellation of physiological systems in the body and evokes a rapid shift in
many neurobehavioral processes. A growing body of work indicates that the …

The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an
animal model of depression more than 20 years ago. The foundation of this model was that …

Deficits in cognitive functioning and flexibility are seen following both chronic stress and
modulation of endogenous cannabinoid (eCB) signaling. Here, we investigated whether …

Secretion of glucocorticoid hormones during stress produces an array of physiological changes
that are adaptive and beneficial in the short term. In the face of repeated stress exposure…

Cannabis is one of the most widely used illicit drugs among adolescents, and most users
first experiment with it in adolescence. Adolescence is a critical phase for brain development, …

Central endocannabinoid signaling is known to be responsive to stressful stimuli; however,
there is no research to date characterizing the effects of stress on peripheral …

Glucocorticoid hormones are secreted in response to stimuli that activate the hypothalamo-pituitary-adrenocortical
(HPA) axis and self-regulate through negative feedback. Negative …

The mechanisms subserving the ability of glucocorticoid signaling within the medial
prefrontal cortex (mPFC) to terminate stress-induced activation of the hypothalamic–pituitary–…