The mammalian brain is one of the organs with the highest energy demands, and mitochondria
are key determinants of its functions. Here we show that the type-1 cannabinoid receptor (…

Balanced control of neuronal activity is central in maintaining function and viability of neuronal
circuits. The endocannabinoid system tightly controls neuronal excitability. Here, we show …

Glial cells produce myelin and contribute to axonal morphology in the nervous system. Two
myelin membrane proteolipids, PLP and DM20, were shown to be essential for the integrity …

Glucagon-like peptide-1 (GLP-1) is a gut peptide that, together with its receptor, GLP-1R, is
expressed in the brain. Here we show that intracerebroventricular (icv) GLP-1 and [Ser(2)]…

Reciprocal interactions between neurons and oligodendrocytes are not only crucial for
myelination, but also for long-term survival of axons. Degeneration of axons occurs in several …

Two proteolipid proteins, PLP and DM20, are the major membrane components of central
nervous system (CNS) myelin. Mutations of the X-linked PLP/DM20 gene cause …

Intrathymic expression of tissue-specific self antigens may be involved in immunological
tolerance and protection from autoimmune disease. We have analyzed the role of T-cell …

Axonal degeneration contributes to clinical disability in the acquired demyelinating disease
multiple sclerosis. Axonal degeneration occurs during acute attacks, associated with …

Local inhibitory circuits are thought to shape neuronal information processing in the central
nervous system, but it remains unclear how specific properties of inhibitory neuronal …

Learning to inhibit drug seeking can be an important strategy for inhibiting relapse, and this
can be modeled by extinguishing drug seeking in response to a drug-paired context. Rats …