Cross-cultural validation of the 5-factor structure of negative symptoms in schizophrenia

…, S Kaiser, M Bischof, MN Hartmann-Riemer… - Schizophrenia …, 2019 - academic.oup.com
Objective Negative symptoms are currently viewed as having a 2-dimensional structure,
with factors reflecting diminished expression (EXP) and motivation and pleasure (MAP). …

The association of neurocognitive impairment with diminished expression and apathy in schizophrenia

MN Hartmann-Riemer, OM Hager, M Kirschner… - Schizophrenia …, 2015 - Elsevier
Negative symptoms can be grouped into the two dimensions of diminished expression and
apathy, which have been shown to be dissociable regarding external validators, such as …

Ventral striatal dysfunction and symptom expression in individuals with schizotypal personality traits and early psychosis

…, L Muff, M Bischof, MN Hartmann-Riemer… - Schizophrenia …, 2018 - academic.oup.com
Striatal abnormalities play a crucial role in the pathophysiology of schizophrenia. Growing
evidence suggests an association between aberrant striatal activity during reward anticipation …

Deficits in context-dependent adaptive coding of reward in schizophrenia

…, OM Hager, M Bischof, MN Hartmann-Riemer… - NPJ …, 2016 - nature.com
Theoretical principles of information processing and empirical findings suggest that to
efficiently represent all possible rewards in the natural environment, reward-sensitive neurons …

Increased random exploration in schizophrenia is associated with inflammation

…, R Schlegel, E Seifritz, MN Hartmann-Riemer… - npj …, 2021 - nature.com
One aspect of goal-directed behavior, which is known to be impaired in patients with schizophrenia
(SZ), is balancing between exploiting a familiar choice with known reward value and …

Reward-dependent modulation of working memory is associated with negative symptoms in schizophrenia

…, M Kirschner, M Bischof, MN Hartmann-Riemer… - Schizophrenia …, 2015 - Elsevier
The negative symptoms of schizophrenia have been associated with altered neural activity
during both reward processing and cognitive processing. Even though increasing evidence …

Clinical, behavioural and neural validation of the PANSS amotivation factor

…, M Kirschner, F Carruzzo, MN Hartmann-Riemer… - Schizophrenia …, 2020 - Elsevier
Negative symptoms in schizophrenia have been suggested to map onto two distinct factors
– amotivation and diminished expression. Only recently, two-factor solutions for measuring …

[HTML][HTML] How far to go in deconstructing negative symptoms? Behavioural and neural level evidence for the amotivation domain

…, M Kirschner, F Carruzzo, MN Hartmann-Riemer… - Schizophrenia …, 2021 - Elsevier
Negative symptoms in schizophrenia are conceptualised as loading onto two factors: amotivation
and diminished expression, which relate to different behavioural and neural markers. …

Deficits in reinforcement learning but no link to apathy in patients with schizophrenia

MN Hartmann-Riemer, S Aschenbrenner, M Bossert… - Scientific reports, 2017 - nature.com
Negative symptoms in schizophrenia have been linked to selective reinforcement learning
deficits in the context of gains combined with intact loss-avoidance learning. Fundamental …

Cerebral blood flow in striatal regions is associated with apathy in patients with schizophrenia

K Schneider, L Michels, MN Hartmann-Riemer… - Journal of Psychiatry and …, 2019 - jpn.ca
Background: Striatal dysfunction has been proposed as a pathomechanism for negative
symptoms in schizophrenia. There is consensus that negative symptoms can be grouped into 2 …