S100B is a calcium‐binding peptide produced mainly by astrocytes that exert paracrine and
autocrine effects on neurons and glia. Some knowledge has been acquired from in vitro and …

Biomarkers are now used in many areas of medicine but are still lacking for psychiatric
conditions such as schizophrenia (SCZ). We have used a multiplex molecular profiling approach …

Recent research efforts have progressively shifted towards preventative psychiatry and
prognostic identification of individuals before disease onset. We describe the development of a …

Much has still to be learned about the molecular mechanisms of depression. This study aims
to gain insight into contributing mechanisms by identifying serum proteins related to major …

Animal studies have suggested neuropeptide S (NPS) and its receptor (NPSR) to be involved
in the pathogenesis of anxiety-related behavior. In this study, a multilevel approach was …

We describe the validation of a serum-based test developed by Rules-Based Medicine which
can be used to help confirm the diagnosis of schizophrenia. In preliminary studies using …

BACKGROUND: Recent studies showed an activation of the cytokine system and the HPA
axis in major depression, although with inconsistent results. While the non-melancholic …

The involvement of immunological and immunopathological mechanisms in the etiopathogenesis
of schizophrenia has been a matter of research, with recently increasing effort. This …

Background: There is evidence that patients with major depression (MD) also suffer an
inflammatory immune reaction. However, the results remain ambiguous. This could be due to the …

The search for immune patterns in major depression has thus far resulted in ambiguous
findings, probably because patient samples are psychiatrically heterogeneous. We therefore …