User profiles for Michael J. Meaney

Michael J Meaney

Singapore Institute for Clinical Sciences (A*STAR)
Verified email at mcgill.ca
Cited by 118789

Epigenetic programming by maternal behavior

…, JR Seckl, S Dymov, M Szyf, MJ Meaney - Nature …, 2004 - nature.com
Here we report that increased pup licking and grooming (LG) and arched-back nursing (ABN)
by rat mothers altered the offspring epigenome at a glucocorticoid receptor (GR) gene …

Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress

…, S Sharma, D Pearson, PM Plotsky, MJ Meaney - Science, 1997 - science.org
Variations in maternal care affect the development of individual differences in neuroendocrine
responses to stress in rats. As adults, the offspring of mothers that exhibited more licking …

Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations

MJ Meaney - Annual review of neuroscience, 2001 - annualreviews.org
▪ Abstract Naturally occurring variations in maternal care alter the expression of genes that
regulate behavioral and endocrine responses to stress, as well as hippocampal synaptic …

Socioeconomic status and the brain: mechanistic insights from human and animal research

DA Hackman, MJ Farah, MJ Meaney - Nature reviews neuroscience, 2010 - nature.com
Human brain development occurs within a socioeconomic context and childhood socioeconomic
status (SES) influences neural development — particularly of the systems that subserve …

Epigenetics and the biological definition of gene× environment interactions

MJ Meaney - Child development, 2010 - Wiley Online Library
Variations in phenotype reflect the influence of environmental conditions during development
on cellular functions, including that of the genome. The recent integration of epigenetics …

Variations in maternal care in the rat as a mediating influence for the effects of environment on development

FA Champagne, DD Francis, A Mar, MJ Meaney - Physiology & behavior, 2003 - Elsevier
Variations in maternal care have been widely considered as a critical influence in development.
In the rat, variations in maternal behavior, particularly in licking/grooming, regulate the …

Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life

…, S Dymov, S Sharma, MJ Meaney… - Journal of …, 2005 - Soc Neuroscience
Stress responses in the adult rat are programmed early in life by maternal care and
associated with epigenomic marking of the hippocampal exon 1 7 glucocorticoid receptor (GR) …

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

…, B Labonté, M Szyf, G Turecki, MJ Meaney - Nature …, 2009 - nature.com
Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through
epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse …

Nongenomic transmission across generations of maternal behavior and stress responses in the rat

D Francis, J Diorio, D Liu, MJ Meaney - Science, 1999 - science.org
In the rat, variations in maternal care appear to influence the development of behavioral and
endocrine responses to stress in the offspring. The results of cross-fostering studies …

Cortisol levels during human aging predict hippocampal atrophy and memory deficits

…, M Thakur, BS McEwen, RL Hauger, MJ Meaney - Nature …, 1998 - nature.com
Elevated glucocorticoid levels produce hippocampal dysfunction and correlate with individual
deficits in spatial learning in aged rats. Previously we related persistent cortisol increases …