3. Localization of corticotropin-releasing factor messenger RNA 432 B. Corticotropin-releasing
factor receptors 433 1. Biochemical charactization of the corticotropin-releasing factor …

Considerable evidence has accrued in the last two decades to support the hypothesis that
alterations in serotonergic neuronal function in the central nervous system occur in patients …

Objective Corticotropin-releasing factor (CRF) and somatostatin both play important roles in
mediating responses to acute and chronic stress. The purpose of this study was to measure …

There is increasing evidence for an important role of adverse early experience on the
development of major psychiatric disorders in adulthood. Corticotropin-releasing factor (CRF), an …

Several new antidepressants that inhibit the serotonin (SERT) and norepinephrine transporters
(NET) have been introduced into clinical practice the past several years. This report …

• Previous studies have provided evidence that corticotropin releasing factor (CRF) is
hypersecreted in patients with major depression. This CRF hypersecretion is believed to contribute …

Advances in the technologic armamentarium available to basic and clinical investigators
have enabled increasingly sophisticated studies of brain function in health and disease. This …

Background: Single isomers of the selective serotonin reuptake inhibitors citalopram (escitalopram,
S-citalopram) and fluoxetine (R-fluoxetine) are currently under development for the …

Background: Prior research has suggested reductions in the density of serotonin transporter
(SERT) binding sites in blood platelets and post-mortem brain tissue of depressed patients. …

The importance of stereochemistry in drug action is gaining greater attention in medical
practice, and a basic knowledge of the subject will be necessary for clinicians to make informed …