User profiles for Michael K. Lee
 | Michael K. LeeProfessor of Neuroscience, University of Minnesota Verified email at umn.edu Cited by 28568 |
[PDF][PDF] Familial Alzheimer's disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo
Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of
early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Aβ1–42…
early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Aβ1–42…
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
Mutations in Cu/Zn superoxide dismutase (SOD1) cause a subset of cases of familial
amyotrophic lateral sclerosis. Four lines of mice accumulating one of these mutant proteins (G37R) …
amyotrophic lateral sclerosis. Four lines of mice accumulating one of these mutant proteins (G37R) …
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase
…, NA Jenkins, NG Copeland, MK Lee… - Human molecular …, 2004 - academic.oup.com
Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and γ-secretase
to release amyloid peptides (Aβ40 and 42) that aggregate to form senile plaques in the …
to release amyloid peptides (Aβ40 and 42) that aggregate to form senile plaques in the …
[PDF][PDF] Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
… The majority of early-onset cases of AD (onset <60 years) are inherited Michael K. Lee,1,
4, … using a polyclonal MycI antiserum (Lee et al., 1993), and subjected recovered PS1myc-…
4, … using a polyclonal MycI antiserum (Lee et al., 1993), and subjected recovered PS1myc-…
[PDF][PDF] Increased expression of α-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
The protein α-synuclein accumulates in the brain of patients with sporadic Parkinson's disease
(PD), and increased gene dosage causes a severe, dominantly inherited form of PD, but …
(PD), and increased gene dosage causes a severe, dominantly inherited form of PD, but …
[PDF][PDF] Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
Missense mutations in two related genes, termed presenilin 1 (PS1) and presenilin 2 (PS2),
cause dementia in a subset of early-onset familial Alzheimer's disease (FAD) pedigrees. In a …
cause dementia in a subset of early-onset familial Alzheimer's disease (FAD) pedigrees. In a …
Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53→ Thr mutation causes neurodegenerative disease with α-synuclein aggregation in …
MK Lee, W Stirling, Y Xu, X Xu, D Qui… - Proceedings of the …, 2002 - National Acad Sciences
Mutations in α-synuclein (α-Syn) cause Parkinson's disease (PD) in a small number of
pedigrees with familial PD. Moreover, α-Syn accumulates as a major component of Lewy bodies …
pedigrees with familial PD. Moreover, α-Syn accumulates as a major component of Lewy bodies …
Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis
A subset of individuals with familial amyotrophic lateral sclerosis (FALS) possesses
dominantly inherited mutations in the gene that encodes copper-zinc superoxide dismutase (…
dominantly inherited mutations in the gene that encodes copper-zinc superoxide dismutase (…
Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
…, NA Jenkins, DL Price, MK Lee - Journal of …, 2006 - Soc Neuroscience
α-Synuclein (α-Syn) is enriched in nerve terminals. Two mutations in the α-Syn gene (Ala53→
Thr and Ala30→ Pro) occur in autosomal dominant familial Parkinson's disease. Mice …
Thr and Ala30→ Pro) occur in autosomal dominant familial Parkinson's disease. Mice …
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.
DR Borchelt, MK Lee, HS Slunt… - Proceedings of the …, 1994 - National Acad Sciences
Familial amyotrophic lateral sclerosis (FALS) has been linked to mutations in the homodimeric
enzyme Cu/Zn superoxide dismutase 1 (SOD1). Assay by transient expression in primate …
enzyme Cu/Zn superoxide dismutase 1 (SOD1). Assay by transient expression in primate …