Synaptic NMDA receptor activation stimulates α-secretase amyloid precursor protein processing and inhibits amyloid-β production
SE Hoey, RJ Williams, MS Perkinton - Journal of Neuroscience, 2009 - Soc Neuroscience
Altered amyloid precursor protein (APP) processing leading to increased production and
oligomerization of Aβ may contribute to Alzheimer's disease (AD). Understanding how APP …
oligomerization of Aβ may contribute to Alzheimer's disease (AD). Understanding how APP …
Phosphatidylinositol 3‐kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones
MS Perkinton, J Ip, GL Wood… - Journal of …, 2002 - Wiley Online Library
Ca 2+ influx through NMDA receptors can initiate molecular changes in neurones which may
underlie synaptic plasticity, neuronal development, survival and excitotoxicity. Signalling …
underlie synaptic plasticity, neuronal development, survival and excitotoxicity. Signalling …
Ca2+-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation …
MS Perkinton, TS Sihra, RJ Williams - Journal of neuroscience, 1999 - Soc Neuroscience
Ca 2+ -permeable AMPA receptors may play a key role during developmental neuroplasticity,
learning and memory, and neuronal loss in a number of neuropathologies. However, the …
learning and memory, and neuronal loss in a number of neuropathologies. However, the …
[HTML][HTML] PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins
…, MP Frosch, J Collinge, DA Harris, MS Perkinton… - Acta …, 2020 - Springer
Neurodegenerative diseases are an enormous public health problem, affecting tens of millions
of people worldwide. Nearly all of these diseases are characterized by oligomerization …
of people worldwide. Nearly all of these diseases are characterized by oligomerization …
Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production
A Vagnoni, MS Perkinton, EH Gray… - Human molecular …, 2012 - academic.oup.com
Understanding the mechanisms that control processing of the amyloid precursor protein (APP)
to produce amyloid-β (Aβ) peptide represents a key area of Alzheimer's disease research. …
to produce amyloid-β (Aβ) peptide represents a key area of Alzheimer's disease research. …
p38α stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis
S Ackerley, AJ Grierson, S Banner, MS Perkinton… - Molecular and Cellular …, 2004 - Elsevier
Neurofilament middle and heavy chains (NFM and NFH) are heavily phosphorylated on
their carboxy-terminal side-arm domains in axons. The mechanisms that regulate this …
their carboxy-terminal side-arm domains in axons. The mechanisms that regulate this …
Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn
S Pezet, M Malcangio, IJ Lever, MS Perkinton… - Molecular and Cellular …, 2002 - Elsevier
Several lines of evidence suggest that the brain-derived neurotrophic factor (BDNF) acts as
central pain neuromodulator.We examined the ability of different types of peripheral …
central pain neuromodulator.We examined the ability of different types of peripheral …
[HTML][HTML] Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α …
…, A Billinton, T Vaughan, I Chessell, MS Perkinton - Neurobiology of …, 2019 - Elsevier
There are no approved drug therapies that can prevent or slow the progression of
Parkinson's disease (PD). Accumulation and aggregation of α-synuclein protein is observed …
Parkinson's disease (PD). Accumulation and aggregation of α-synuclein protein is observed …
Cellular prion protein mediates the disruption of hippocampal synaptic plasticity by soluble tau in vivo
…, M Gardener, J Hammersley, MS Perkinton… - Journal of …, 2018 - Soc Neuroscience
Intracellular neurofibrillary tangles (NFTs) composed of tau protein are a neuropathological
hallmark of several neurodegenerative diseases, the most common of which is Alzheimer's …
hallmark of several neurodegenerative diseases, the most common of which is Alzheimer's …
[HTML][HTML] Dietary (−)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing
CJ Cox, F Choudhry, E Peacey, MS Perkinton… - Neurobiology of …, 2015 - Elsevier
Flavonoids, a group of dietary polyphenols have been shown to possess cognitive health
benefits. Epidemiologic evidence suggests that they could play a role in risk reduction in …
benefits. Epidemiologic evidence suggests that they could play a role in risk reduction in …