We investigated the metabolism of human brown adipose tissue (BAT) in healthy subjects
by determining its cold-induced and insulin-stimulated glucose uptake and blood flow (…

α 2 -Adrenergic receptors in brain are important presynaptic modulators of central noradrenergic
function (autoreceptors) and postsynaptic mediators of many of the widespread effects …

… Ewen MacDonald, Brian Kobilka and Mika Scheinin describe how these mice may be
utilized to elucidate the physiological functions of the receptor subtypes and the properties of …

The effects of dexmedetomidine, an alpha 2-adrenoceptor agonist, on vigilance, thiopental
anesthetic requirements, and the hemodynamic, catecholamine, and hormonal responses to …

Dexmedetomidine is a selective alpha 2-adrenoceptor agonist with centrally mediated
sympatholytic, sedative, and analgesic effects. This study evaluated: 1) pharmacokinetics of …

Background In celiac disease, small intestinal transglutaminase 2 causes deamidation of
glutamine residues in gluten peptides, which enhances stimulation of T cells and leads to …

Dexmedetomidine, a selective α 2 ‐adrenoceptor agonist, was administered to five healthy
male volunteers in single intravenous doses of 12.5, 25, 50, and 75 µg as part of a placebo‐…

Background— The anti-ischemic agent trimetazidine improves ejection fraction in heart failure
that is hypothetically linked to inhibitory effects on cardiac free fatty acid (FFA) oxidation. …

Purpose The aim of this proof-of-concept study was to characterize the pharmacokinetics
and pharmacodynamics of intranasal dexmedetomidine compared with its intravenous …

Dopaminergic deficiency in the brain of zebrafish was produced by systemic administration
of two catecholaminergic neurotoxins, 6‐hydroxydopamine (6‐OHDA) and 1‐methyl‐4‐…