Mitochondria are particularly vulnerable to oxidative stress, and mitochondrial swelling and
vacuolization are among the earliest pathologic features found in two strains of transgenic …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of
Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal …

The development of biomarkers for the diagnosis and monitoring disease progression in
Parkinson's disease (PD) is of great importance since diagnosis based on clinical parameters …

Background The risk of Parkinson disease (PD) and its rate of progression may decline with
increasing concentration of blood urate, a major antioxidant. Objective To determine …

Although the cause of amyotrophic lateral sclerosis (ALS) is unknown, substantial evidence
indicates that oxidative toxicity is associated with neuronal death in this disease. We …

Publisher Summary A primary role of lipids in cellular function is in the formation of the
permeability barrier of cells and subcellular organelles in the form of a lipid bilayer. This chapter …

Glutathione peroxidase (GSHPx) is a critical intracellular enzyme involved in detoxification
of hydrogen peroxide (H 2 O 2 ) to water. In the present study we examined the susceptibility …

The topology of polytopic membrane proteins is determined by topogenic sequences in the
protein, protein-translocon interactions, and interactions during folding within the protein and …

To address the role of phospholipids in the topological organization of polytopic membrane
proteins, the function and assembly of lactose permease (LacY) was studied in mutants of …

… M Bogdanov, E Mileykovskaya, W Dowhan, Lipids in the assembly of membrane proteins
and organization of protein supercomplexes: Implications for lipid-linked … Mikhail Bogdanov …