Here we report that increased pup licking and grooming (LG) and arched-back nursing (ABN)
by rat mothers altered the offspring epigenome at a glucocorticoid receptor (GR) gene …

Early life experiences shape an individual's physical and mental health across the lifespan.
Not surprisingly, an upbringing that is associated with adversity can produce detrimental …

Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through
epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse …

Stress responses in the adult rat are programmed early in life by maternal care and
associated with epigenomic marking of the hippocampal exon 1 7 glucocorticoid receptor (GR) …

Environmental effects on the materno–foetal interaction determine birth outcomes that predict
health over the lifespan. Thus, maternal undernutrition or stress associate with low birth …

We used a collection of 708 prospectively collected autopsied brains to assess the methylation
state of the brain's DNA in relation to Alzheimer's disease (AD). We found that the level of …

DNA-methylation patterns are important for regulating genome functions, and are determined
by the enzymatic processes of methylation and demethylation. The demethylating enzyme …

Early experience permanently alters behavior and physiology. These effects are, in part,
mediated by sustained alterations in gene expression in selected brain regions. The critical …

Early-life experience has long-term consequences on behavior and stress responsivity of
the adult. We previously proposed that early-life experience results in stable epigenetic …

It is widely acknowledged that the nature of the maternal care a child receives can have long-term
repercussions, and that children raised in deprived environments can have severe …