The disrupted in schizophrenia 1 (DISC1) gene is a candidate susceptibility factor for
schizophrenia, but its mechanistic role in the disorder is unknown. Here we report that the gene …

Type-A receptors for the neurotransmitter GABA (γ-aminobutyric acid) are ligand-gated
chloride channels that mediate inhibitory neurotransmission. Each subunit of the pentameric …

Estrogens have long been implicated in influencing cognitive processes, yet the molecular
mechanisms underlying these effects and the roles of the estrogen receptors alpha (ERα) and …

Synaptic spines are dynamic structures that regulate neuronal responsiveness and plasticity.
We examined the role of the schizophrenia risk factor DISC1 in the maintenance of spine …

Recent advances in our understanding of the underlying genetic architecture of psychiatric
disorders has blown away the diagnostic boundaries that are defined by currently used …

Schizophrenia (SZ) is primarily an adult psychiatric disorder in which disturbances caused
by susceptibility genes and environmental insults during early neurodevelopment initiate …

Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …

Following several recent reports that suggest that dual cAMP and cGMP phosphodiesterase
10A (PDE10A) inhibitors may present a novel mechanism to treat positive symptoms of …

Estrogen, in addition to its genomic effects in brain, causes rapid and reversible changes to
synaptic operations. We report here that these acute actions are due to selective activation of …

Disrupted-in-Schizophrenia-1 (DISC1), identified by positional cloning of a balanced translocation
(1;11) with the breakpoint in intron 8 of a large Scottish pedigree, is associated with a …