User profiles for Nicolai Franzmeier

Nicolai Franzmeier

Junior Research Group Leader, Institute for Stroke and Dementia Research, Ludwig …
Verified email at med.uni-muenchen.de
Cited by 4600

[HTML][HTML] Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease

N Franzmeier, J Neitzel, A Rubinski, R Smith… - Nature …, 2020 - nature.com
In Alzheimer’s diseases (AD), tau pathology is strongly associated with cognitive decline.
Preclinical evidence suggests that tau spreads across connected neurons in an activity-…

Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease

N Franzmeier, A Dewenter, L Frontzkowski… - Science …, 2020 - science.org
In Alzheimer’s disease (AD), the Braak staging scheme suggests a stereotypical tau spreading
pattern that does, however, not capture interindividual variability in tau deposition. This …

[HTML][HTML] Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer's disease

A Pichet Binette, N Franzmeier, N Spotorno… - Nature …, 2022 - nature.com
For optimal design of anti-amyloid-β (Aβ) and anti-tau clinical trials, we need to better
understand the pathophysiological cascade of Aβ- and tau-related processes. Therefore, we set …

Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases

…, S Lindner, C Spitz, N Franzmeier… - Science translational …, 2021 - science.org
2-Deoxy-2-[ 18 F]fluoro-d-glucose positron emission tomography (FDG-PET) is widely used
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease

M Ewers, N Franzmeier, M Suárez-Calvet… - Science translational …, 2019 - science.org
Loss of function of TREM2, a key receptor selectively expressed by microglia in the brain,
contributes to the development of Alzheimer’s disease (AD). We therefore examined whether …

Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance

…, G Chetelat, M Ewers, N Franzmeier… - Alzheimer's & …, 2020 - Wiley Online Library
Several concepts, which in the aggregate get might be used to account for “resilience”
against age‐ and disease‐related changes, have been the subject of much research. These …

Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease

…, RJ Bateman, C Habeck, Y Stern, N Franzmeier… - Brain, 2021 - academic.oup.com
Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer’s
disease, but the functional brain mechanisms that support cognitive resilience remain elusive. …

[HTML][HTML] Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational …

…, Y Li, B Nuscher, N Franzmeier… - The Lancet …, 2022 - thelancet.com
Background Therapeutic modulation of TREM2-dependent microglial function might provide
an additional strategy to slow the progression of Alzheimer's disease. Although studies in …

[HTML][HTML] Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

…, MÁ Araque Caballero, N Franzmeier… - Molecular …, 2019 - Springer
Background TREM2 is a transmembrane receptor that is predominantly expressed by microglia
in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-…

Functional connectivity associated with tau levels in ageing, Alzheimer's, and small vessel disease

N Franzmeier, A Rubinski, J Neitzel, Y Kim, A Damm… - Brain, 2019 - academic.oup.com
In Alzheimer’s disease, tau pathology spreads hierarchically from the inferior temporal lobe
throughout the cortex, ensuing cognitive decline and dementia. Similarly, circumscribed …