User profiles for Nicolai Franzmeier
Nicolai FranzmeierJunior Research Group Leader, Institute for Stroke and Dementia Research, Ludwig … Verified email at med.uni-muenchen.de Cited by 4600 |
[HTML][HTML] Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease
In Alzheimer’s diseases (AD), tau pathology is strongly associated with cognitive decline.
Preclinical evidence suggests that tau spreads across connected neurons in an activity-…
Preclinical evidence suggests that tau spreads across connected neurons in an activity-…
Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease
N Franzmeier, A Dewenter, L Frontzkowski… - Science …, 2020 - science.org
In Alzheimer’s disease (AD), the Braak staging scheme suggests a stereotypical tau spreading
pattern that does, however, not capture interindividual variability in tau deposition. This …
pattern that does, however, not capture interindividual variability in tau deposition. This …
[HTML][HTML] Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer's disease
For optimal design of anti-amyloid-β (Aβ) and anti-tau clinical trials, we need to better
understand the pathophysiological cascade of Aβ- and tau-related processes. Therefore, we set …
understand the pathophysiological cascade of Aβ- and tau-related processes. Therefore, we set …
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases
…, S Lindner, C Spitz, N Franzmeier… - Science translational …, 2021 - science.org
2-Deoxy-2-[ 18 F]fluoro-d-glucose positron emission tomography (FDG-PET) is widely used
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …
Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease
Loss of function of TREM2, a key receptor selectively expressed by microglia in the brain,
contributes to the development of Alzheimer’s disease (AD). We therefore examined whether …
contributes to the development of Alzheimer’s disease (AD). We therefore examined whether …
Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance
Several concepts, which in the aggregate get might be used to account for “resilience”
against age‐ and disease‐related changes, have been the subject of much research. These …
against age‐ and disease‐related changes, have been the subject of much research. These …
Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease
Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer’s
disease, but the functional brain mechanisms that support cognitive resilience remain elusive. …
disease, but the functional brain mechanisms that support cognitive resilience remain elusive. …
[HTML][HTML] Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational …
…, Y Li, B Nuscher, N Franzmeier… - The Lancet …, 2022 - thelancet.com
Background Therapeutic modulation of TREM2-dependent microglial function might provide
an additional strategy to slow the progression of Alzheimer's disease. Although studies in …
an additional strategy to slow the progression of Alzheimer's disease. Although studies in …
[HTML][HTML] Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
…, MÁ Araque Caballero, N Franzmeier… - Molecular …, 2019 - Springer
Background TREM2 is a transmembrane receptor that is predominantly expressed by microglia
in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-…
in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-…
Functional connectivity associated with tau levels in ageing, Alzheimer's, and small vessel disease
In Alzheimer’s disease, tau pathology spreads hierarchically from the inferior temporal lobe
throughout the cortex, ensuing cognitive decline and dementia. Similarly, circumscribed …
throughout the cortex, ensuing cognitive decline and dementia. Similarly, circumscribed …