Protein complexes are key molecular entities that integrate multiple gene products to
perform cellular functions. Here we report the first genome-wide screen for complexes in an …

Just as reference genome sequences revolutionized human genetics, reference maps of
interactome networks will be critical to fully understand genotype-phenotype relationships. Here…

Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships 1 , 2 . …

While alternative splicing is known to diversify the functional characteristics of some genes,
the extent to which protein isoforms globally contribute to functional complexity on a …

Network-centered approaches are increasingly used to understand the fundamentals of biology.
However, the molecular details contained in the interaction networks, often necessary to …

A correlation analysis of the amino acid composition and the cellular location of a protein is
presented. The statistical analysis discriminates among the following five protein classes: …

Images of entire cells are preceding atomic structures of the separate molecular machines
that they contain. The resulting gap in knowledge can be partly bridged by protein-protein …

Protein–protein interactions are central to most biological processes. Although much recent
effort has been put into methods to identify interacting partners, there has been a limited …

Much of systems biology aims to predict the behaviour of biological systems on the basis of
the set of molecules involved. Understanding the interactions between these molecules is …

Network and systems biology offer a novel way of approaching drug discovery by developing
models that consider the global physiological environment of protein targets, and the …