Background Lithium has been used clinically for 70 years, mainly to treat bipolar disorder.
Competing treatments and exaggerated impressions about complexity and risks of lithium …

There has been increasing interest in the use of smartphone applications (apps) and other
consumer technology in mental health care for a number of years. However, the vision of data …

Background: This article is a selective review and synthesis of relevant research findings
from genetic studies of major mood disorders and the application of these to clinical practice. …

Background Lithium is a first-line treatment in bipolar disorder, but individual response is
variable. Previous studies have suggested that lithium response is a heritable trait. However, …

Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide
association studies (GWAS) have robustly identified the first common genetic variants involved …

Background: Selecting a drug according to the treatment response in a relative has been
widely accepted advice in the management of mood disorders. However, this recommendation …

Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage.
The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD …

BACKGROUND: Numerous studies have observed that offspring of bipolar parents manifest
a broad spectrum of psychiatric disorders. We tested the hypothesis that in high risk offspring…

Objective: A major aim of this longitudinal high‐risk study is to identify reliable early indicators
of emerging bipolar disorder (BD) among offspring from well‐characterized parents. …

BackgroundBipolar disorder is highly heritable and therefore longitudinal observation of
children of affected parents is important to mapping the early natural history.AimsTo model the …