Psychostimulant drugs like amphetamine are readily self-administered by humans and
laboratory animals by virtue of their actions on dopamine (DA) neurons in the midbrain. Exposing …

A major hurdle in defining the molecular biology of nicotine addiction has been characterizing
the different nicotinic acetylcholine receptor (nAChR) subtypes in the brain and how …

Repeated intermittent exposure to amphetamine produces long-term enhancements in the
ability of this drug to produce locomotion and increase extracellular dopamine (DA) in the …

Stimulant drugs such as amphetamine are readily self-administered by humans and laboratory
animals by virtue of their actions on dopamine (DA) neurons of the midbrain. Repeated …

The effect of dopamine (DA) receptor blockade on the development of sensitization to the
locomotor activating effects of systemic amphetamine and intra-ventral tegmental area (intra-…

Different groups of rats received conditioning training with bilateral injections of amphetamine
(2.5 μg/0.5 μl/side) either into the ventral tegmental area (VTA) or the nucleus accumbens (…

Repeated intermittent exposure to psychostimulants can lead to long-lasting sensitization of
the drugs’ behavioral and biochemical effects. Such findings have figured importantly in …

Addictions are commonly presaged by problems in childhood and adolescence. For many
individuals this starts with the early expression of impulsive risk-taking, social gregariousness, …

The present experiment examined the contribution of locomotor response to novelty and prior
exposure to amphetamine to rats’ predisposition to self-administer a low dose of the drug. …

Susceptibility to addictive behaviors has been related to both increases and decreases in
striatal function. Both profiles have been reported in humans as well as in animal models. Yet, …