Recent advances in deriving induced pluripotent stem (iPS) cells from patients offer new
possibilities for biomedical research and clinical applications, as these cells could be used for …

Autologous transplantation of patient-specific induced pluripotent stem cell (iPSC)-derived
neurons is a potential clinical approach for treatment of neurological disease. Preclinical …

N-Methyl-d-aspartate (NMDA) glutamate receptors are a class of excitatory amino acid
receptors, which have several important functions in the motor circuits of the basal ganglia, and …

Interactions between dopaminergic and glutamatergic afferents in the striatum are essential
for motor learning and the regulation of movement. An important mechanism for these …

The development of dyskinesias and other motor complications greatly limits the use of
levodopa therapy in Parkinson's disease (PD). Studies in rodent models of PD suggest that an …

To determine the long-term health and function of transplanted dopamine neurons in
Parkinson's disease (PD) patients, the expression of dopamine transporters (DATs) and …

Diminished lysosomal function can lead to abnormal cellular accumulation of specific
proteins, including α-synuclein, contributing to disease pathogenesis of vulnerable neurons in …

Aims: Loss-of-function mutations in GBA1, which cause the autosomal recessive lysosomal
storage disease, Gaucher disease (GD), are also a key genetic risk factor for the α-…

In Parkinson's disease (PD), loss of striatal dopaminergic (DA) terminals and degeneration
of DA neurons in the substantia nigra (SN) are associated with glial reactions. Such …

Background Haploinsufficiency in the Gaucher disease GBA gene, which encodes the
lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for developing …