Understanding human cortical maturation is a central goal for developmental neuroscience.
Significant advances toward this goal have come from two recent strands of in vivo structural …

Growing access to large-scale longitudinal structural neuroimaging data has fundamentally
altered our understanding of cortical development en route to human adulthood, with …

Understanding of human structural brain development has rapidly advanced in recent years,
but remains fundamentally "localizational" in nature. Here, we use 376 longitudinally …

Expression of imprinted genes is restricted to a single parental allele as a result of
epigenetic regulation—DNA methylation and histone modifications. Igf2/H19 is a reciprocally …

Human astrocytic brain tumors select for mutations in the p53 tumor suppressor gene early
in malignant progression. p53 is activated upon various kinds of cellular stress leading to …

The tumor suppressor gene p53, implicated in diverse types of human tumors, functions both
as a gene-specific transcription factor as well as a specific inhibitor of the transcription of …

The INK4a-ARF locus encodes two tumor suppressor proteins involved in cell-cycle regulation,
p16 INK4a and p14 ARF , whose functions are inactivated in many human cancers. The …

Anaerobic ammonium oxidation (anammox) is both a promising process in wastewater
treatment and a long overlooked microbial physiology that can contribute significantly to …

The carboxy-terminus of p53 contains a basic region which represses DNA binding, and
this repression can be relieved by PAb421, an antibody against the basic region. The EB-1 …

The major urinary proteins (MUPs) of the mouse are encoded by a multigene family located
at the Mup a locus on chromosome 4. Previous investigations have shown that the MUPs are …