Abnormal metabolic network activity in Parkinson's disease: test—retest reproducibility
Y Ma, C Tang, PG Spetsieris… - Journal of Cerebral …, 2007 - journals.sagepub.com
Parkinson's disease (PD) is associated with an abnormal pattern of regional brain function.
The expression of this PD-related covariance pattern (PDRP) has been used to assess …
The expression of this PD-related covariance pattern (PDRP) has been used to assess …
Functional brain networks in DYT1 dystonia
…, T Nakamura, V Dhawan, P Spetsieris… - Annals of …, 1998 - Wiley Online Library
Early‐onset idiopathic torsion dystonia (ITD) is an autosomal dominant hyperkinetic movement
disorder with incomplete penetrance, associated with a 3 base‐pair deletion in the DYT1 …
disorder with incomplete penetrance, associated with a 3 base‐pair deletion in the DYT1 …
Metabolic network abnormalities in early Huntington's disease: an [18F] FDG PET study
…, J Missimer, G Kuenig, P Spetsieris… - Journal of Nuclear …, 2001 - Soc Nuclear Med
The identification of discrete patterns of altered functional brain circuitry in preclinical
Huntington’s disease (HD) gene carriers is important to understanding the pathophysiology of this …
Huntington’s disease (HD) gene carriers is important to understanding the pathophysiology of this …
Scaled subprofile modeling of resting state imaging data in Parkinson's disease: methodological issues
PG Spetsieris, D Eidelberg - Neuroimage, 2011 - Elsevier
Consistent functional brain abnormalities in Parkinson's disease (PD) are difficult to pinpoint
because differences from the normal state are often subtle. In this regard, the application of …
because differences from the normal state are often subtle. In this regard, the application of …
Differential diagnosis of parkinsonian syndromes using PCA-based functional imaging features
PG Spetsieris, Y Ma, V Dhawan, D Eidelberg - Neuroimage, 2009 - Elsevier
In the current paper, we describe methodologies for single subject differential diagnosis of
degenerative brain disorders using multivariate principal component analysis (PCA) of …
degenerative brain disorders using multivariate principal component analysis (PCA) of …
Microstructural white matter changes in carriers of the DYT1 gene mutation
…, S Su, GS Smith, P Spetsieris… - Annals of Neurology …, 2004 - Wiley Online Library
We tested the hypothesis that the DYT1 genotype is associated with a disorder of anatomical
connectivity involving primarily the sensorimotor cortex. We used diffusion tensor magnetic …
connectivity involving primarily the sensorimotor cortex. We used diffusion tensor magnetic …
Metabolic resting-state brain networks in health and disease
PG Spetsieris, JH Ko, CC Tang… - Proceedings of the …, 2015 - National Acad Sciences
The delineation of resting state networks (RSNs) in the human brain relies on the analysis of
temporal fluctuations in functional MRI signal, representing a small fraction of total neuronal …
temporal fluctuations in functional MRI signal, representing a small fraction of total neuronal …
[PDF][PDF] Assessment of disease severity in parkinsonism with fluorine-18-fluorodeoxyglucose and PET
…, T Ishikawa, V Dhawan, P Spetsieris… - Journal of Nuclear …, 1995 - Soc Nuclear Med
PD patients. We then assessthe relationshipbetweenthese
metabolicmeasuresandobjectiveindependentdiseaseseverfty ratings. Methods: …
metabolicmeasuresandobjectiveindependentdiseaseseverfty ratings. Methods: …
Identification of disease-related spatial covariance patterns using neuroimaging data
P Spetsieris, Y Ma, S Peng, JH Ko, V Dhawan… - JoVE (Journal of …, 2013 - jove.com
The scaled subprofile model (SSM)1-4 is a multivariate PCA-based algorithm that identifies
major sources of variation in patient and control group brain image data while rejecting …
major sources of variation in patient and control group brain image data while rejecting …
Metabolic correlates of pallidal neuronal activity in Parkinson's disease.
…, D Sterio, V Dhawan, P Spetsieris… - Brain: a journal of …, 1997 - academic.oup.com
We have used [18F]fluorodeoxyglucose and PET to identify specific metabolic covariance
patterns associated with Parkinson's disease and related disorders previously. Nonetheless, …
patterns associated with Parkinson's disease and related disorders previously. Nonetheless, …