Several neurotransmitters have been implicated in the pathophysiology of major depression.
Reduced activity of the 5-HT and the noradrenaline systems has been reported in sub-…

Extensive studies showed that monoaminergic neurotransmission that involves serotonin (5-HT),
norepinephrine (NE) and dopamine (DA) exerts major influence on brain circuits …

To investigate the contribution of individual serotonin (5-hydroxytryptamine; 5-HT) receptors
to mood control, we have used homologous recombination to generate mice lacking specific …

Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted
a revision of the 2009 guidelines by updating the evidence and recommendations. The …

Background Anxiety and related disorders are among the most common mental disorders,
with lifetime prevalence reportedly as high as 31%. Unfortunately, anxiety disorders are under-…

At clinically relevant doses, selective serotonin (5-HT) reuptake inhibitors (SSRIs) and MAO
inhibitors (MAOIs) increase the extracellular concentration of 5-HT in the midbrain raphé …

The role of serotonin (5-hydroxytryptamine; 5-HT) in the treatment of depressive and anxiety
disorders is underscored by the therapeutic action of selective 5-HT reuptake inhibitors …

The existence of an endogenous vasoconstrictor in blood serum (Stevens and Lee, 1984;
Brodie, 1900) and the presence in the gut of a substance that increases intestinal motility (…

The sustained administration of the 5‐HT 1A agonist gepirone (15 mg/kg/day, sc) in the rat
produced an initial decrease of the firing activity of dorsal raphe 5‐HT neurons which was …

Mitochondria possess their own genetic material (mitochondrial DNA or mtDNA), whose
gene products are involved in mitochondrial respiration and oxidative phosphorylation, …