Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
Common variants conferring risk of schizophrenia
…, T Werge, OPH Pietiläinen, O Mors, PB Mortensen… - Nature, 2009 - nature.com
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
[PDF][PDF] The Danish civil registration system
…, H Gøtzsche, JØ Møller, PB Mortensen - Dan Med …, 2006 - content.ugeskriftet.dk
Background: The Danish Civil Registration System (CRS) was established in 1968, where
all persons alive and living in Denmark were registered. Among many other variables, it …
all persons alive and living in Denmark were registered. Among many other variables, it …
[PDF][PDF] Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders
…, SE Medland, JL Moran, O Mors, PB Mortensen… - Cell, 2019 - cell.com
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
Autoimmune diseases and severe infections as risk factors for mood disorders: a nationwide study
…, WW Eaton, J Krogh, PB Mortensen - JAMA …, 2013 - jamanetwork.com
Importance Mood disorders frequently co-occur with medical diseases that involve
inflammatory pathophysiologic mechanisms. Immune responses can affect the brain and might …
inflammatory pathophysiologic mechanisms. Immune responses can affect the brain and might …
Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study
Objective: Autoimmune diseases have been associated with an increased risk of schizophrenia.
It has been suggested that brain-reactive autoantibodies are part of the mechanisms …
It has been suggested that brain-reactive autoantibodies are part of the mechanisms …
Neonatal vitamin D status and risk of schizophrenia: a population-based case-control study
…, DM Hougaard, PB Mortensen - Archives of general …, 2010 - jamanetwork.com
Context Clues from the epidemiology of schizophrenia suggest that low levels of developmental
vitamin D may be associated with increased risk of schizophrenia. Objective To directly …
vitamin D may be associated with increased risk of schizophrenia. Objective To directly …
Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice
…, M Voget, R Willi, C Winter, MA Riva, PB Mortensen… - Science, 2013 - science.org
Prenatal infection and exposure to traumatizing experiences during peripuberty have each
been associated with increased risk for neuropsychiatric disorders. Evidence is lacking for …
been associated with increased risk for neuropsychiatric disorders. Evidence is lacking for …
[HTML][HTML] International meta-analysis of PTSD genome-wide association studies identifies sex-and ancestry-specific genetic risk loci
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust
common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD …
common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD …