It has been established that oxidative stress, defined as the condition in which the sum of
free radicals in a cell exceeds the antioxidant capacity of the cell, contributes to the …

The biochemical and cellular changes that occur following administration of 1-methyl-4-phenyl-1,
2, 3, 6-tetrahydropyridine (MPTP) are remarkably similar to that seen in idiopathic …

The brain is in many ways an immunologically and pharmacologically privileged site. The
blood–brain barrier (BBB) of the cerebrovascular endothelium and its participation in the …

NERVE growth factor (NGF) induces neurite outgrowth and promotes survival of embryonic
sensory and sympathetic neurons in culture 1,2 . In vivo, NGF decreases the extent of …

THE development of a multicellular organism involves a delicate balance among the
processes of proliferation, differentiation and death. Naturally occurring cell death aids tissue …

We have generated mice carrying a germline mutation in the tyrosine kinase catalytic
domain of the trkB gene. This mutation eliminates expression of gp145 trkB , a protein-tyrosine …

THE trkC gene 1,2 is expressed throughout the mammalian nervous system 3-5 and encodes
a series of tyrosine protein kinase isoforms that serve as receptors for neurotrophin-3 (NT3)…

The DNA-binding activity of AP-1 proteins is modulated, in vitro, by a posttranslational
mechanism involving reduction oxidation. This mode of regulation has been proposed to control …

Oxidative stress has been implicated in the etiology of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP) animal model of PD. It is known that …

Somatic inactivation of PTEN occurs in different human tumors including glioblastoma,
endometrial carcinoma and prostate carcinoma. Germline mutations in PTEN result in a range of …