Context A substantial proportion of people at clinical high risk (HR) of psychosis will develop
a psychotic disorder over time. Cognitive deficits may predate the onset of psychosis and …

Background The profile of cortical neuroanatomical abnormalities in schizophrenia is not
fully understood, despite hundreds of published structural brain imaging studies. This study …

Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain
abnormalities, we do not know to what extent such abnormalities reflect the effects of …

To date, the MRI-based individualized prediction of psychosis has only been demonstrated
in single-site studies. It remains unclear if MRI biomarkers generalize across different centers …

We conducted a systematic review to assess the evidence for specific effects of cannabis on
impulsivity, disinhibition and motor control. The review had a specific focus on …

Importance Brain imaging studies have identified robust changes in brain structure and function
during the development of psychosis, but the contribution of abnormal brain connectivity …

Background Negative emotional states and abnormal stress reactivity are central components
in drug addiction. The brain stress system in the amygdala is thought to play a key role in …

Brain changes in schizophrenia evolve along a dynamic trajectory, emerging before disease
onset and proceeding with ongoing illness. Recent investigations have focused attention …

Importance The behavioral and cognitive symptoms of severe psychotic disorders overlap
with those seen in dementia. However, shared brain alterations remain disputed, and their …

Background A key clinical challenge in the management of individuals at clinical high risk
for psychosis (CHR) is that it is difficult to predict their future clinical outcomes. Here, we …