User profiles for Robert K. McNamara

Robert K. McNamara, Ph.D.

Professor of Psychiatry and Behavioral Neuroscience
Verified email at uc.edu
Cited by 12842

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

…, Y Xia, D Maciejewski, RK McNamara… - Proceedings of the …, 1998 - National Acad Sciences
A recently identified chemokine, fractalkine, is a member of the chemokine gene family, which
consists principally of secreted, proinflammatory molecules. Fractalkine is distinguished …

Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology

RK McNamara, SE Carlson - Prostaglandins, Leukotrienes and Essential …, 2006 - Elsevier
The principle omega-3 fatty acid in brain, docosahexaenoic acid (DHA), accumulates in the
brain during perinatal cortical expansion and maturation. Animal studies have demonstrated …

Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats

RL Huot, PM Plotsky, RH Lenox, RK McNamara - Brain research, 2002 - Elsevier
Neonatal maternal separation of rat pups leads to a stable stress hyper-responsive phenotype
characterized by increased basal levels of corticotropin releasing factor (CRF) mRNA in …

The neuropharmacological and neurochemical basis of place learning in the Morris water maze

RK McNamara, RW Skelton - Brain Research Reviews, 1993 - Elsevier
The Morris water maze (MWM) offers several advantages over other methods of studying
the neurochemical basis of learning and memory, particularly with respect to its ability to …

Duloxetine 60 mg once daily dosing versus placebo in the acute treatment of major depression

MJ Detke, Y Lu, DJ Goldstein, RK McNamara… - Journal of psychiatric …, 2002 - Elsevier
Existing therapies for major depressive disorder (MDD) have either limited efficacy and/or
poor tolerability. The present study examined the effects of duloxetine, a potent and balanced …

Duloxetine in the acute and long-term treatment of major depressive disorder: a placebo-and paroxetine-controlled trial

…, CG Wiltse, CH Mallinckrodt, RK McNamara… - European …, 2004 - Elsevier
Background: Duloxetine is a balanced and potent dual reuptake inhibitor of serotonin (5-HT)
and norepinephrine (NE) that has previously been shown to be effective in the acute …

Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder

RK McNamara, CG Hahn, R Jandacek, T Rider… - Biological …, 2007 - Elsevier
BACKGROUND: Epidemiological surveys and peripheral tissue (red blood cells/plasma)
fatty acid composition studies suggest that omega-3 fatty acid deficiency is associated with …

[HTML][HTML] Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging …

RK McNamara, J Able, R Jandacek, T Rider… - The American journal of …, 2010 - Elsevier
Background: Emerging evidence suggests that docosahexaenoic acid (DHA, 22:6n−3), the
principal omega-3 (n−3) fatty acid in brain gray matter, positively regulates cortical metabolic …

Neuroprogression in bipolar disorder

MR Schneider, MP DelBello, RK McNamara… - Bipolar …, 2012 - Wiley Online Library
Schneider MR, DelBello MP, McNamara RK, Strakowski SM, Adler CM. Neuroprogression
in bipolar disorder. Bipolar Disord 2012: 14: 356–374. © 2012 The Authors. Journal …

International society for nutritional psychiatry research practice guidelines for omega-3 fatty acids in the treatment of major depressive disorder

…, J Hibbeln, RK McNamara, K Hamazaki… - Psychotherapy and …, 2019 - karger.com
Major depressive disorder (MDD) is a complex mental illness with unmet therapeutic needs.
The antidepressant effects of ω–3 polyunsaturated fatty acids (n–3 PUFAs) have been …