A current hypothesis links the neuroexcitatory properties of certain acidic amino acids to
their ability to cause selective neuronal lesions. Intracerebral injection of the neuroexcitatory …

The essential amino acid tryptophan is not only a precursor of serotonin but is also
degraded to several other neuroactive compounds, including kynurenic acid, 3-hydroxykynurenine …

To evaluate the potential contribution of circulating kynurenines to brain kynurenine pools,
the rates of cerebral uptake and mechanisms of blood–brain barrier transport were …

THE symptoms of Huntington's chorea, an hereditary movement disorder, result from
degeneration of neurones primarily in the basal ganglia 1 . Several neurochemical abnormalities …

The tryptophan metabolite kynurenic acid (KYNA) has long been recognized as an NMDA
receptor antagonist. Here, interactions between KYNA and the nicotinic system in the brain …

Background: Metabolites of the kynurenine pathway of tryptophan degradation may play a
role in the pathogenesis of several human brain diseases. One of the key metabolites in this …

Degradation of the essential amino acid tryptophan along the kynurenine pathway (KP)
yields several neuroactive intermediates, including the free radical generator 3-…

Metabolites in the kynurenine pathway, generated by tryptophan degradation, are thought
to play an important role in neurodegenerative disorders, including Alzheimer's and …

Kynurenic acid (KYNA) was tested as an antagonist of the neurotoxic and epileptogenic
effects of the metabolically related brain constituent quinolinic acid (QUIN). In the rat striatum, …

PURPOSE: To compare success rates of external dacryocystorhinostomy (DCR) and
endoscopic endonasal DCR for acquired nasolacrimal duct obstruction (NLDO). DESIGN: …