Alzheimer’s disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and
neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration…

Altered processing of the amyloid precursor protein (APP) is a central event in the formation
of amyloid deposits in the brains of individuals with Alzheimer's disease. To investigate …

To determine whether neurodegeneration in Alzheimer disease brain is associated with
degradation of structural cell membrane molecules, we measured tissue levels of the major …

To test whether antibodies against β-amyloid are effective in slowing progression of Alzheimer's
disease, we assessed cognitive functions in 30 patients who received a prime and a …

Stress triggers a cascade of physiological events including glucocorticoid secretion from the
adrenal cortex, which can influence memory function1–13. Exogenous glucocorticoids …

Background Transthyretin amyloid (ATTR) cardiomyopathy is a progressive and fatal disease
caused by misfolded transthyretin. Despite advances in slowing disease progression, …

Mutations in the microtubule-associated protein tau, including P301L, are genetically coupled
to hereditary frontotemporal dementia with parkinsonism linked to chromosome 17. To …

The physiological functions of the beta-amyloid precursor protein (APP) may include
nuclear signaling. To characterize the role of the APP adaptor proteins Fe65, Jip1b, X11α (MINT1) …

Previous work indicates that stress levels of circulating glucocorticoids can impair retrieval
of declarative memory in human subjects. Several studies have reported that declarative …

OBJECTIVE: Because elevated cortisol levels inhibit memory retrieval in healthy human
subjects, the present study investigated whether cortisol administration might also reduce …