… BP ND refers to the ratio at equilibrium of specifically bound radioligand to that of nondisplaceable
radioligand in tissue. BP ND is the typical measurement from reference tissue methods, as it …

Dopaminergic neurotransmission may be involved in learning, reinforcement of behaviour,
attention, and sensorimotor integration 1 , 2 . Binding of the radioligand 11 C-labelled …

Background Background Activated microglia have a key role in the brain's immune response
to neuronal degeneration. The transition of microglia from the normal resting state to the …

A method is presented for the generation of parametric images of radioligand–receptor binding
using PET. The method is based on a simplified reference region compartmental model, …

Synaptic dopamine release from embryonic nigral transplants has been monitored in the
striatum of a patient with Parkinson's disease using [11 C]-raclopride positron emission …

Background Pharmacological and postmortem investigations suggest that patients with major
depressive disorder have alterations in function or density of brain serotonin 1A (5-HT 1A ) …

[ 11 C]PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron emission
tomography (PET) to detect microglial activation. However, quantitative interpretations of …

The current article presents theory for compartmental models used in positron emission
tomography (PET). Both plasma input models and reference tissue input models are considered. …

… from donors with a history of MS (n = 13), donors without any history of neurologic disease
(n = 20), and in platelets from healthy volunteers (n = 13). Binding potential estimates from …

[ 11 C]-(+)-PHNO is a D3 preferring PET radioligand which has recently opened the
possibility of imaging D3 receptors in the human brain in vivo. This imaging tool allows …