Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.
…, TK Li, SP Wang, YT Lin, RB Lu… - American journal of …, 1991 - ncbi.nlm.nih.gov
The liver enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH),
which are responsible for the oxidative metabolism of ethanol, are polymorphic in humans. An …
which are responsible for the oxidative metabolism of ethanol, are polymorphic in humans. An …
[PDF][PDF] Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism
CC Chen, RB Lu, YC Chen, MF Wang… - The American Journal of …, 1999 - cell.com
The genes that encode the major enzymes of alcohol metabolism, alcohol dehydrogenase (ADH)
and aldehyde dehydrogenase (ALDH), exhibit functional polymorphism. The variant …
and aldehyde dehydrogenase (ALDH), exhibit functional polymorphism. The variant …
Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons
…, ML Block, CC Wang, H Kinyamu, N Lu… - International Journal …, 2008 - academic.oup.com
Parkinson's disease (PD) is characterized by the selective and progressive loss of dopaminergic
(DA) neurons in the midbrain substantia nigra. Currently, available treatment is unable …
(DA) neurons in the midbrain substantia nigra. Currently, available treatment is unable …
[HTML][HTML] Anti-herpetic medications and reduced risk of dementia in patients with herpes simplex virus infections—a nationwide, population-based cohort study in …
This retrospective cohort study is to investigate the association between herpes simplex
virus (HSV) infections and dementia, and the effects of anti-herpetic medications on the risk …
virus (HSV) infections and dementia, and the effects of anti-herpetic medications on the risk …
Developing a SNP panel for forensic identification of individuals
…, NJ Karoma, S Kungulilo, JJ Kim, RB Lu… - Forensic science …, 2006 - Elsevier
Single nucleotide polymorphisms (SNPs) are likely in the near future to have a fundamental
role in forensics in both human identification and description. However, considerable …
role in forensics in both human identification and description. However, considerable …
[PDF][PDF] A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity
…, J Bertranpetit, B Bonne-Tamir, RB Lu… - The American Journal of …, 2002 - cell.com
Variants of different Class I alcohol dehydrogenase (ADH) genes have been shown to be
associated with an effect that is protective against alcoholism. Previous work from our …
associated with an effect that is protective against alcoholism. Previous work from our …
[HTML][HTML] Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial …
…, SM Rawls, P Flood, JS Hong, RB Lu - …, 2009 - nature.com
Memantine shows clinically relevant efficacy in patients with Alzheimer's disease and
Parkinson's disease. Most in vivo and in vitro studies attribute the neuroprotective effects of …
Parkinson's disease. Most in vivo and in vitro studies attribute the neuroprotective effects of …
[PDF][PDF] Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism
…, JF Lee, SJ Yin, HC Ko, HJ Edenberg, RB Lu… - The American Journal of …, 1999 - cell.com
Two of the three class I alcohol dehydrogenase (ADH) genes (ADH2 and ADH3) encode
known functional variants that act on alcohol with different efficiencies. Variants at both these …
known functional variants that act on alcohol with different efficiencies. Variants at both these …
The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination
…, NJ Karoma, S Kungulilo, RB Lu… - Annals of human …, 2004 - Wiley Online Library
The catalytic deficiency of human aldehyde dehydrogenase 2 (ALDH2) is caused by a
nucleotide substitution (G1510A; Glu487Lys) in exon 12 of the ALDH2 locus. This SNP, and four …
nucleotide substitution (G1510A; Glu487Lys) in exon 12 of the ALDH2 locus. This SNP, and four …
The measurement of caregiver burden
KR Chou, H Chu, CL Tseng, RB Lu - Journal of Medical Sciences, 2003 - airitilibrary.com
The assessment of burden has become a challenging task for most researchers because
cultural, ethical, religious and other personal values may influence perceptions of meaning and …
cultural, ethical, religious and other personal values may influence perceptions of meaning and …
