Protein kinase C (PKC), which comprises 11 closely related isoforms, has been implicated
in a wide variety of cellular processes, such as growth, differentiation, secretion, apoptosis …

The balanced action of cytokines is known to be critical for the maintenance of homeostatic
immune responses. Here, we report the development of an inflammatory skin disease …

Seven-color analyses of immunofluorescence-stained tissue samples were accomplished
using Fourier spectroscopy-based hyperspectral imaging and singular value decomposition. …

B7 homologous protein (B7h)/B7-related protein 1 (B7RP-1) is a new member of the B7
family of costimulatory molecules that specifically interacts with inducible costimulator (ICOS) …

B7-H1 (CD274) is a T-cell coinhibitory molecule that is also often induced on human carcinoma
cells, where its expression has been implicated in immune escape. Under inflammatory …

Autoimmune diseases involve multiple genes. While functions of these genes are largely
unknown, some may be related to an intrinsic hyperresponsiveness of B cells. B-cell responses …

Abstract Development of either Th1 or Th2 cell subsets has profound immunologic consequences,
either pathogenic or protective, in several autoimmune diseases. However, it remains …

Inducible costimulator (ICOS)-B7 homologous protein (B7h) is a new member of the CD28-B7
family of costimulatory molecules that regulates T cell-dependent humoral immune …

Programmed death‐1 (PD‐1) and its ligands, B7‐H1/PD‐L1 and B7‐DC/PD‐L2, are new
CD28‐B7 family members that may be involved in the regulation of immune responses. We …

Serotonin [5-hydroxytryptamine (5-HT)] is a major therapeutic target of psychiatric disorders.
Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5-HT…