Objective: A prevalence of at least 30% for treatment-resistant depression has prompted the
investigation of alternative treatment strategies. Deep brain stimulation (DBS) is a promising …

The resurgence of interest in anhedonia within major depression has been fuelled by
clinical trials demonstrating its utility in predicting antidepressant response as well as recent …

Object Deep brain stimulation (DBS) has been recently investigated as a treatment for major
depression. One of the proposed targets for this application is the subcallosal cingulate …

To demonstrate the clinical effectiveness of an antidepressant drug requires evidence beyond
short- and long-term efficacy, including a favourable adverse-effect profile and sustained …

Anhedonia, a core symptom of Major Depressive Disorder (MDD), is predictive of
antidepressant non-response. In contrast to the definition of anhedonia as a “loss of pleasure”, …

Objective: Treatment-resistant depression (TRD) represents a considerable global health
concern. The goal of the InSight study was to investigate the prevalence of TRD and to …

Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …

… , and dopamine is likely present, although the majority of research linking dopamine
dysregulation to reward processing is derived from preclinical models.81, 82 However, Rizvi19 …

Objective: Major depressive disorder (MDD) is a leading cause of disability. Impairment in
work function considerably adds to symptom burden and increases the economic impact of …

Introduction Suicide attempts are a significant global public health concern. Research into
non-traditional factors, such as the presence of alexithymia, may shed light on the prediction …