Huntington's disease (HD) is a fatal dominantly inherited neurodegenerative disorder caused
by a CAG repeat expansion leading to an elongated polyglutamine stretch in huntingtin 1 . …

To make an appropriate decision, one must anticipate potential future rewarding events,
even when they are not readily observable. These expectations are generated by using …

The prevailing view is that striatal parvalbumin (PV)-positive interneurons primarily function
to downregulate medium spiny projection neuron (MSN) activity via monosynaptic inhibitory …

In Huntington's disease (HD) mouse models, spontaneous inhibitory synaptic activity is
enhanced in a subpopulation of medium-sized spiny neurons (MSNs), which could dampen …

The discovery of the HD (Huntington's disease) gene in 1993 led to the creation of genetic
mouse models of the disease and opened the doors for mechanistic studies. In particular, the …

10.7554/eLife.08352.001 Striatal dysfunction plays an important role in dystonia, but the
striatal cell types that contribute to abnormal movements are poorly defined. We demonstrate …

Huntington's disease (HD) is an inherited neurodegenerative disorder with no disease-modifying
treatment. Expansion of the glutamine-encoding repeat in the Huntingtin (HTT) gene …

Neural stem/progenitor cell (NS/PC)‐based therapies have shown exciting potential for
regeneration of the central nervous system (CNS) and NS/PC cultures represent an important …

Adaptive reward-related decision making often requires accurate and detailed representation
of potential available rewards. Environmental reward-predictive stimuli can facilitate these …

The pathological hallmark of Huntington's disease ( HD ) is the massive loss of striatal and
cortical neurons. Until recently, it was believed that striatal interneurons were spared from …