M 1 muscarinic acetylcholine receptors (mAChRs) may represent a viable target for treatment
of disorders involving impaired cognitive function. However, a major limitation to testing …

Osteoporosis is the most common bone disease, affecting millions of people worldwide and
leading to significant morbidity and high expenditure. Most of the current therapies available …

Previous clinical and animal studies suggest that selective activators of M 1 and/or M 4
muscarinic acetylcholine receptors (mAChRs) have potential as novel therapeutic agents for …

This report describes the discovery and initial characterization of the first positive allosteric
modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5). Functional HTS, …

Cholinergic transmission in the forebrain is mediated primarily by five subtypes of muscarinic
acetylcholine receptors (mAChRs), termed M 1 −M 5 . Of the mAChR subtypes, M 1 is …

Aims Many patients are unable to achieve guideline-recommended LDL cholesterol (LDL-C)
targets, despite taking maximally tolerated lipid-lowering therapy. Bempedoic acid, a …

Therapeutic monoclonal antibodies (mAbs) exhibit limited distribution to the target tissues.
Determination of target tissue interstitial concentration of mAbs is an important aspect in the …

Microdialysis is a validated and well-established technique for recovering and measurement
of exogenous as well as endogenous small molecules in the interstitial spaces of various …

Population pharmacokinetics (popPK) of bempedoic acid and the popPK/pharmacodynamic
(popPK/PD) relationship between bempedoic acid concentrations and serum low-density …

Glutamate is the major excitatory transmitter in the mammalian central nervous system (CNS),
exerting its effects through both ionotropic and metabotropic glutamate receptors. The …