Prognostic and predictive factors are indispensable tools in the treatment of patients with
neoplastic disease. For the most part, such factors rely on a few specific cell surface, histological…

We have used high-density DNA microarrays to provide an analysis of gene regulation
during the mammalian cell cycle and the role of E2F in this process. Cell cycle analysis was …

Assay systems using in vitro cultured cells are increasingly applied for evaluation of the
efficacy, safety, and toxicity of drug candidates. In vitro cell-based assays have two main …

Previous work has demonstrated the important role of E2F transcription activity in the induction
of S phase during the transition from quiescence to proliferation. In addition to the E2F-…

E2F transcription factors are major regulators of cell proliferation. The diversity of the E2F
family suggests that individual members perform distinct functions in cell cycle control. E2F4 …

High-density DNA microarrays measure expression of large numbers of genes in one assay.
The ability to find underlying structure in complex gene expression data sets and rigorously …

The tumor suppressor function of Rb is intimately related to its ability to interact with E2F and
repress the transcription of E2F target genes. Here we describe a novel E2F product that …

We have generated mice deficient in E2F4 activity, the major form of E2F in many cell types.
Analysis of newborn pups deficient in E2F4 revealed abnormalities in hematopoietic lineage …

Patients with chronic hepatitis C viral infection underwent liver biopsies and laboratory
studies for evaluation and to determine subsequent treatment. Changes in status of drug …

Human hepatocellular carcinoma (HCC) heterogeneity promotes recurrence and resistance
to therapies. Recent studies have reported that HCC may be derived not only from adult …