Most depressed patients don't respond to their first drug treatment, and the reasons for this
treatment resistance remain enigmatic. Human studies implicate a polymorphism in the …

The actions of androgens in both peripheral and central tissues are linked in part to their
ability to specifically bind and activate androgen receptors (ARs). ARs have been well studied …

The median (MR) and dorsal raphe (DR) nuclei contain the majority of the 5-hydroxytryptamine
(5-HT, serotonin) neurons that project to limbic forebrain regions, are important in …

Identifying the factors contributing to the etiology of anxiety and depression is critical for the
development of more efficacious therapies. Serotonin (5-HT) is intimately linked to both …

Serotonin (5-HT) modulates neural responses to socioaffective cues and can bias approach
or avoidance behavioral decisions, yet the cellular mechanisms underlying its contribution …

Background Despite seventeen decades of continuous clinical use, the neuronal mechanisms
through which volatile anesthetics act to produce unconsciousness remain obscure. One …

The dorsal (DR) and median raphe (MR) nuclei contain 5-hydroxytryptamine (serotonin, 5-HT)
cell bodies that give rise to the majority of the ascending 5-HT projections to the forebrain …

… Beck and Collin Challis designed the electrophysiology experiments and Sheryl G. Beck
trained Collin Challis for whole-cell recording and slice optogenetics and overviewed …

Genetic variations in certain components of the glucocorticoid receptor (GR) chaperone
complex have been associated with the development of stress-related affective disorders and …

Serotonin receptor 1A knockout (Htr1a KO ) mice show increased anxiety-related behavior
in tests measuring innate avoidance. Here we demonstrate that Htr1a KO mice show …