User profiles for Sho Kakizawa

Sho Kakizawa

京都大学大学院薬学研究科准教授
Verified email at kyoto-u.ac.jp
Cited by 2853

Critical period for activity-dependent synapse elimination in developing cerebellum

S Kakizawa, M Yamasaki, M Watanabe… - Journal of …, 2000 - Soc Neuroscience
Synapse elimination is considered to be the final step in neural circuit formation, by causing
refinement of redundant connections formed at earlier developmental stages. The …

Nitric oxide‐induced calcium release via ryanodine receptors regulates neuronal function

S Kakizawa, T Yamazawa, Y Chen, A Ito… - The EMBO …, 2012 - embopress.org
Mobilization of intracellular Ca 2+ stores regulates a multitude of cellular functions, but the
role of intracellular Ca 2+ release via the ryanodine receptor (RyR) in the brain remains …

[HTML][HTML] A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke

…, X Liu, C Diggle, PD Allen, S Kakizawa… - Nature …, 2021 - nature.com
Mutations in the type 1 ryanodine receptor (RyR1), a Ca 2+ release channel in skeletal muscle,
hyperactivate the channel to cause malignant hyperthermia (MH) and are implicated in …

PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellum

…, K Hashimoto, RS Petralia, S Kakizawa… - Journal of …, 2001 - Soc Neuroscience
Membrane-associated guanylate kinases (MAGUKs) are abundant postsynaptic density (PSD)-95/discs
large/zona occludens-1 (PDZ)-containing proteins that can assemble receptors …

[PDF][PDF] TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance

…, M Nishi, H Yamamura, S Yamamoto, S Kakizawa… - Cell metabolism, 2011 - cell.com
TRIC channel subtypes, namely TRIC-A and TRIC-B, are intracellular monovalent cation
channels postulated to mediate counter-ion movements facilitating physiological Ca 2+ release …

Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization

…, C Sato, F Aoyama, A Sawaguchi, S Kakizawa… - Science …, 2016 - science.org
The trimeric intracellular cation (TRIC) channels TRIC-A and TRIC-B localize predominantly
to the endoplasmic reticulum (ER) and likely support Ca 2+ release from intracellular stores …

Junctophilin‐mediated channel crosstalk essential for cerebellar synaptic plasticity

S Kakizawa, Y Kishimoto, K Hashimoto… - The EMBO …, 2007 - embopress.org
Functional crosstalk between cell‐surface and intracellular ion channels plays important roles
in excitable cells and is structurally supported by junctophilins (JPs) in muscle cells. Here, …

[PDF][PDF] Visualization of IP3 dynamics reveals a novel AMPA receptor-triggered IP3 production pathway mediated by voltage-dependent Ca2+ influx in Purkinje cells

Y Okubo, S Kakizawa, K Hirose, M Iino - Neuron, 2001 - cell.com
IP 3 signaling in Purkinje cells is involved in the regulation of cell functions including LTD.
We have used a GFP-tagged pleckstrin homology domain to visualize IP 3 dynamics in …

Elevation of Plasma Somatolactin Concentrations During Acidosis in Rainbow Trout (Oncorhynchus Mykiss)

S Kakizawa, T Kaneko, T Hirano - Journal of experimental …, 1996 - journals.biologists.com
Somatolactin (SL) is a putative pituitary hormone of the growth hormone (GH)/prolactin (PRL)
family in fish; its physiological function has yet to be determined. Acidosis was induced in …

C-type natriuretic peptide facilitates autonomic Ca2+ entry in growth plate chondrocytes for stimulating bone growth

…, Y Ueda, I Yamauchi, T Hakata, K Nakao, S Kakizawa… - Elife, 2022 - elifesciences.org
The growth plates are cartilage tissues found at both ends of developing bones, and vital
proliferation and differentiation of growth plate chondrocytes are primarily responsible for bone …