Oxidative stress has been implicated in the pathogenesis of neurologic and psychiatric
diseases. The brain is particularly vulnerable to oxidative damage due to high oxygen …

BACKGROUND: Social stress leads to oxidative stress in the central nervous system,
contributing to the development of mental disorders. Loss of parvalbumin in interneurons is an …

Although its involvement in prion replication and neurotoxicity during transmissible spongiform
encephalopathies is undisputed, the physiological role of the cellular prion protein (PrP C …

Neurodegenerative disease are frequently characterized by microglia activation and/or
leukocyte infiltration in the parenchyma of the central nervous system and at the molecular level …

Prions induce lethal neurodegeneration and consist of PrP Sc, an aggregated conformer of
the cellular prion protein PrP C. Antibody-derived ligands to the globular domain of PrP C (…

Subanesthetic doses of NMDA receptor antagonist ketamine induce schizophrenia-like
symptoms in humans and behavioral changes in rodents. Subchronic administration of ketamine …

The expression and the role of the chemokine receptor CCR5 have been mainly studied in
the context of HIV infection. However, this protein is also expressed in the brain, where it can …

Among the pathogenic mechanisms underlying central nervous system (CNS) diseases,
oxidative stress is almost invariably described. For this reason, numerous attempts have been …

Reactive oxygen species (ROS) generation by microglia is implicated in neuroinflammation
and neurotoxicity, as well as in host defense, cell proliferation and excitatory amino acid …

Prion infections cause neurodegeneration, which often goes along with oxidative stress.
However, the cellular source of reactive oxygen species (ROS) and their pathogenetic …