Background Neuroimaging of cerebral blood flow (CBF) can inform our understanding of the
pathophysiology of bipolar disorder (BD) as there is increasing support for the concept that …

Background: Bipolar disorder (BD) is one of the most heritable medical conditions, and
certain phenotypic characteristics are especially familial in BD. BD is also strongly associated …

Objective Building on prior findings in adults, this study investigated regional cerebral blood
flow (CBF) in relation to DSM-5 criterion A symptoms of depression and mania in youth with …

Numerous pharmacological treatments for mood disorders are currently available; however,
rates of treatment resistance, relapse and recurrence remain high. Therefore, novel …

Adolescence is a period of rapid development of the brain’s inherent functional and structural
networks; however, little is known about the region-to-region organization of adolescent …

Objectives Bipolar disorder ( BD ) is twice as prevalent amongst female as amongst male
adolescents. Thus far, little is known regarding the neurostructural substrates underlying this …

Objectives: To compare demographic, clinical, and familial characteristics across bipolar
disorder (BD) subtypes in adolescents. Methods: A total of 168 participants, 13 to 19 years of …

Objectives: Neuroimaging studies of adults with bipolar disorder (BD) have identified several
BD subtype distinctions, including greater deficits in prefrontal gray matter volumes in BD-I (…

Background Multiple prior studies have examined cerebral blood flow (CBF) in relation to
mood states in adults with bipolar disorder (BD). We set out examine CBF in regards to mood …

While extensive work has been conducted regarding risk factors for suicide attempts and
deaths, clinical prediction of suicide-related behaviour at an individual level remains an unmet …