User profiles for Simon D. Kyle

Simon D. Kyle

University of Oxford
Verified email at ndcn.ox.ac.uk
Cited by 10326

A randomized, placebo-controlled trial of online cognitive behavioral therapy for chronic insomnia disorder delivered via an automated media-rich web application

CA Espie, SD Kyle, C Williams, JC Ong, NJ Douglas… - Sleep, 2012 - academic.oup.com
Study Objectives: The internet provides a pervasive milieu for healthcare delivery. The
purpose of this study was to determine the effectiveness of a novel web-based cognitive …

Insomnia and health-related quality of life

SD Kyle, K Morgan, CA Espie - Sleep medicine reviews, 2010 - Elsevier
Health-related Quality of Life (HRQoL) has become an important construct in contemporary
medicine and health care, permitting assessment of disorder burden and evaluation of …

[HTML][HTML] Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

…, J Bowden, BE Cade, M Garaulet, SD Kyle… - Nature …, 2019 - nature.com
Sleep is an essential state of decreased activity and alertness but molecular factors regulating
sleep duration remain unknown. Through genome-wide association analysis in 446,118 …

The Sleep Condition Indicator: a clinical screening tool to evaluate insomnia disorder

CA Espie, SD Kyle, P Hames, M Gardani, L Fleming… - BMJ open, 2014 - bmjopen.bmj.com
Objective Describe the development and psychometric validation of a brief scale (the Sleep
Condition Indicator (SCI)) to evaluate insomnia disorder in everyday clinical practice. Design …

Effect of digital cognitive behavioral therapy for insomnia on health, psychological well-being, and sleep-related quality of life: a randomized clinical trial

CA Espie, R Emsley, SD Kyle, C Gordon… - JAMA …, 2019 - jamanetwork.com
Importance Digital cognitive behavioral therapy (dCBT) is a scalable and effective intervention
for treating insomnia. Most people with insomnia, however, seek help because of the …

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

…, AI Luik, A Loudon, FAJL Scheer, SM Purcell, SD Kyle… - Nature …, 2017 - nature.com
Chronic sleep disturbances, associated with cardiometabolic diseases, psychiatric disorders
and all-cause mortality 1 , 2 , affect 25–30% of adults worldwide 3 . Although environmental …

[HTML][HTML] Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank

JM Lane, I Vlasac, SG Anderson, SD Kyle… - Nature …, 2016 - nature.com
Our sleep timing preference, or chronotype, is a manifestation of our internal biological clock.
Variation in chronotype has been linked to sleep disorders, cognitive and physical …

Biological and clinical insights from genetics of insomnia symptoms

…, CJ Willer, S Redline, K Spiegelhalder, SD Kyle… - Nature …, 2019 - nature.com
Insomnia is a common disorder linked with adverse long-term medical and psychiatric
outcomes. The underlying pathophysiological processes and causal relationships of insomnia …

Insomnia disorder: State of the science and challenges for the future

…, R Wassing, AL Henry, SD Kyle… - Journal of sleep …, 2022 - Wiley Online Library
Insomnia disorder comprises symptoms during night and day that strongly affect quality of
life and wellbeing. Prolonged sleep latency, difficulties to maintain sleep and early morning …

The evidence base of sleep restriction therapy for treating insomnia disorder

CB Miller, CA Espie, DR Epstein, L Friedman… - Sleep medicine …, 2014 - Elsevier
Sleep restriction therapy is routinely used within cognitive behavioral therapy to treat chronic
insomnia. However, the efficacy for sleep restriction therapy as a standalone intervention …