Protein aggregation is the hallmark of neurodegeneration, but the molecular mechanisms
underlying late-onset Alzheimer’s disease (AD) are unclear. Here we integrated transcriptomic…

H1 linker histones are the most abundant chromatin-binding proteins 1 . In vitro studies
indicate that their association with chromatin determines nucleosome spacing and enables …

Epigenetic states defined by chromatin can be maintained through mitotic cell division.
However, it remains unknown how histone-based information is transmitted. Here we combine …

Interactions between noncoding RNAs and chromatin proteins play important roles in gene
regulation, but the molecular details of most of these interactions are unknown. Using protein-…

It is becoming increasingly clear that transcription factors operate in complex networks
through thousands of genomic binding sites, many of which bind several transcription factors. …

Efferocytosis, the clearance of apoptotic cells (ACs) by macrophages, is critical for tissue
resolution, with defects driving many diseases. Mechanisms of efferocytosis-mediated …

Pancreatic cancer is among the deadliest of human malignancies. We identify a key role for
the metabolic enzyme ACLY, which produces acetyl-CoA, in pancreatic carcinogenesis. The …

Nucleosomes are the smallest structural unit of chromatin, composed of 147 base pairs of
DNA wrapped around an octamer of histone proteins. Histone function is mediated by …

Over the last decade, numerous histone acyl post-translational modifications (acyl-PTMs)
have been discovered, of which the functional significance is still under intense study. Here, …

Heterochromatin is integral to cell identity maintenance by impeding the activation of genes
for alternate cell fates. Heterochromatic regions are associated with histone 3 lysine 9 …