High-throughput sequencing of the transcriptome and chromatin accessibility in the same cell
Single-cell RNA sequencing can reveal the transcriptional state of cells, yet provides little
insight into the upstream regulatory landscape associated with open or accessible chromatin …
insight into the upstream regulatory landscape associated with open or accessible chromatin …
Fiber‐based wearable electronics: a review of materials, fabrication, devices, and applications
Fiber‐based structures are highly desirable for wearable electronics that are expected to be
light‐weight, long‐lasting, flexible, and conformable. Many fibrous structures have been …
light‐weight, long‐lasting, flexible, and conformable. Many fibrous structures have been …
High-efficiency inverted dithienogermole–thienopyrrolodione-based polymer solar cells
Inverted polymer bulk heterojunction solar cells have received a great deal of attention
because of their compatibility with large-scale roll-to-roll processing. The inverted cell geometry …
because of their compatibility with large-scale roll-to-roll processing. The inverted cell geometry …
A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo
Nanoscale robots have potential as intelligent drug delivery systems that respond to
molecular triggers 1 , 2 , 3 , 4 . Using DNA origami we constructed an autonomous DNA robot …
molecular triggers 1 , 2 , 3 , 4 . Using DNA origami we constructed an autonomous DNA robot …
Favipiravir versus arbidol for COVID-19: a randomized clinical trial
…, Y Zhang, Z Cheng, J Wu, S Chen, Y Zhang, B Chen… - MedRxiv, 2020 - medrxiv.org
Importance WHO has made the assessment that coronavirus disease 2019 (COVID-19) can
be characterized as a pandemic. So far, there is no clinically proven effective antiviral drug …
be characterized as a pandemic. So far, there is no clinically proven effective antiviral drug …
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration
Targeted genome editing via engineered nucleases is an exciting area of biomedical research
and holds potential for clinical applications. Despite rapid advances in the field, in vivo …
and holds potential for clinical applications. Despite rapid advances in the field, in vivo …
Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain
…, HL Fung, S Chen, R Vijayaraghavan, J Wong, A Chen… - Science, 2016 - science.org
The human brain has enormously complex cellular diversity and connectivities fundamental
to our neural functions, yet difficulties in interrogating individual neurons has impeded …
to our neural functions, yet difficulties in interrogating individual neurons has impeded …
A novel kernelized fuzzy c-means algorithm with application in medical image segmentation
Image segmentation plays a crucial role in many medical imaging applications. In this paper,
we present a novel algorithm for fuzzy segmentation of magnetic resonance imaging (MRI) …
we present a novel algorithm for fuzzy segmentation of magnetic resonance imaging (MRI) …
Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain
Detailed characterization of the cell types in the human brain requires scalable experimental
approaches to examine multiple aspects of the molecular state of individual cells, as well as …
approaches to examine multiple aspects of the molecular state of individual cells, as well as …
DNA origami as a carrier for circumvention of drug resistance
Although a multitude of promising anti-cancer drugs have been developed over the past 50
years, effective delivery of the drugs to diseased cells remains a challenge. Recently, …
years, effective delivery of the drugs to diseased cells remains a challenge. Recently, …