User profiles for Song Chen

Song Chen

- Verified email at sanger.ac.uk - Cited by 5355

Song Chen

- Verified email at suda.edu.cn - Cited by 4566

Chen Song

- Verified email at lroc.harvard.edu - Cited by 2087

High-throughput sequencing of the transcriptome and chromatin accessibility in the same cell

S Chen, BB Lake, K Zhang - Nature biotechnology, 2019 - nature.com
Single-cell RNA sequencing can reveal the transcriptional state of cells, yet provides little
insight into the upstream regulatory landscape associated with open or accessible chromatin …

Fiber‐based wearable electronics: a review of materials, fabrication, devices, and applications

W Zeng, L Shu, Q Li, S Chen, F Wang… - Advanced …, 2014 - Wiley Online Library
Fiber‐based structures are highly desirable for wearable electronics that are expected to be
light‐weight, long‐lasting, flexible, and conformable. Many fibrous structures have been …

High-efficiency inverted dithienogermole–thienopyrrolodione-based polymer solar cells

CE Small, S Chen, J Subbiah, CM Amb, SW Tsang… - Nature …, 2012 - nature.com
Inverted polymer bulk heterojunction solar cells have received a great deal of attention
because of their compatibility with large-scale roll-to-roll processing. The inverted cell geometry …

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

S Li, Q Jiang, S Liu, Y Zhang, Y Tian, C Song… - Nature …, 2018 - nature.com
Nanoscale robots have potential as intelligent drug delivery systems that respond to
molecular triggers 1 , 2 , 3 , 4 . Using DNA origami we constructed an autonomous DNA robot …

Favipiravir versus arbidol for COVID-19: a randomized clinical trial

…, Y Zhang, Z Cheng, J Wu, S Chen, Y Zhang, B Chen… - MedRxiv, 2020 - medrxiv.org
Importance WHO has made the assessment that coronavirus disease 2019 (COVID-19) can
be characterized as a pandemic. So far, there is no clinically proven effective antiviral drug …

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

…, M Kurita, T Hishida, M Li, E Aizawa, S Guo, S Chen… - Nature, 2016 - nature.com
Targeted genome editing via engineered nucleases is an exciting area of biomedical research
and holds potential for clinical applications. Despite rapid advances in the field, in vivo …

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain

…, HL Fung, S Chen, R Vijayaraghavan, J Wong, A Chen… - Science, 2016 - science.org
The human brain has enormously complex cellular diversity and connectivities fundamental
to our neural functions, yet difficulties in interrogating individual neurons has impeded …

A novel kernelized fuzzy c-means algorithm with application in medical image segmentation

DQ Zhang, SC Chen - Artificial intelligence in medicine, 2004 - Elsevier
Image segmentation plays a crucial role in many medical imaging applications. In this paper,
we present a novel algorithm for fuzzy segmentation of magnetic resonance imaging (MRI) …

Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain

BB Lake, S Chen, BC Sos, J Fan, GE Kaeser… - Nature …, 2018 - nature.com
Detailed characterization of the cell types in the human brain requires scalable experimental
approaches to examine multiple aspects of the molecular state of individual cells, as well as …

DNA origami as a carrier for circumvention of drug resistance

Q Jiang, C Song, J Nangreave, X Liu… - Journal of the …, 2012 - ACS Publications
Although a multitude of promising anti-cancer drugs have been developed over the past 50
years, effective delivery of the drugs to diseased cells remains a challenge. Recently, …