Objective To assess axonal damage and its contribution to disability at different stages of
multiple sclerosis (MS). Background Recent in vivo imaging and in situ pathologic studies have …

It has been difficult to establish a strong correlation between total brain T2-weighted lesion
volume on MRI and clinical disability in multiple sclerosis, in part because of the lack of …

Magnetic resonance (MR) imaging is often used to characterize and quantify multiple sclerosis
(MS) lesions in the brain and spinal cord. The number and volume of lesions have been …

Background HLA-DRB1*15 genotype, previous infection with Epstein-Barr virus, and
vitamin D insufficiency are susceptibility factors for multiple sclerosis, but whether they act …

The myelin g-ratio, defined as the ratio between the inner and the outer diameter of the
myelin sheath, is a fundamental property of white matter that can be computed from a simple …

Background There are limited treatments for progressive multiple sclerosis. Ibudilast inhibits
several cyclic nucleotide phosphodiesterases, macrophage migration inhibitory factor, and …

Background Fatigue is a common and distressing symptom for patients with multiple
sclerosis (MS). There is growing evidence that fatigue in MS has a central nervous system …

The spinal cord is frequently affected by atrophy and/or lesions in multiple sclerosis (MS)
patients. Segmentation of the spinal cord and lesions from MRI data provides measures of …

Background Multiple sclerosis (MS) diagnostic criteria incorporate MRI features that can be
used to predict later diagnosis of MS in adults with acute CNS demyelination. To identify MRI …

Background Although in situ pathological studies and in vivo magnetic resonance (MR)
investigations have shown that axonal injury can be significant in the early stages of multiple …