Rationale Kappa opioid receptors (KORs) have been implicated in depressive-like states
associated with chronic administration of drugs of abuse and stress. Although KOR agonists …

Drug-evoked plasticity at excitatory synapses on medium spiny neurons (MSNs) of the
nucleus accumbens (NAc) drives behavioral adaptations in addiction. MSNs expressing …

Adaptive motivated behavior requires rapid discrimination between beneficial and harmful
stimuli. Such discrimination leads to the generation of either an approach or rejection …

The development of diet-induced obesity (DIO) can potently alter multiple aspects of dopamine
signaling, including dopamine transporter (DAT) expression and dopamine reuptake. …

Repeated exposure to psychostimulant drugs such as cocaine or amphetamine can promote
drug-seeking and-taking behavior. In rodent addiction models, persistent changes in …

Understanding the neurobiological processes that incite drug craving and drive relapse has
the potential to help target efforts to treat addiction. The NAc serves as a critical substrate for …

Experience-dependent synaptic plasticity is an important component of both learning and
motivational disturbances found in addicted individuals. Here, we investigated the role of …

Our everyday behavior is energized by the desire to maximize beneficial, rewarding outcomes
while minimizing harmful ones. Brain circuitry has evolved to strengthen associations …

The development of diet-induced obesity (DIO) can potently alter multiple aspects of dopamine
signaling, including dopamine transporter (DAT) expression and dopamine reuptake. …

Purpose: To retrospectively compare the accuracy of digital versus film mammography in
population subgroups of the Digital Mammographic Imaging Screening Trial (DMIST) defined …