The purpose of the present investigation was to examine the topographical organization of
efferent projections from the cytoarchitectonic divisions of the mPFC (the medial precentral, …

Excitatory projections from the prefrontal cortex (PFC) to the ventral tegmental area (VTA)
play an important role in regulating the activity of VTA neurons and the extracellular levels of …

Many of the brain's reward systems converge on the nucleus accumbens, a region richly
innervated by excitatory, inhibitory, and modulatory afferents representing the circuitry …

Physiological and pharmacological studies indicate that descending projections from the
prefrontal cortex modulate dopaminergic transmission in the nucleus accumbens septi and …

Parkinson disease is a common neurodegenerative disorder that leads to difficulty in
effectively translating thought into action. Although it is known that dopaminergic neurons that …

The dopamine transporter (DAT) critically regulates the duration of the cellular actions of
dopamine and the extent to which dopamine diffuses in the extracellular space. We sought to …

Potential cellular substrates for functions ascribed to the dopamine D2 receptor were
examined in rat brain using immunoperoxidase for localization of a D2 receptor peptide and …

… The results of this investigation have been previously presented in preliminary form (Sesack …
onto common targets within the PFC (Carr and Sesack, 1998) and it is possible, though not …

For normal regulation of motor, affective, and cognitive functions, dopamine provides an
essential modulation of glutamate transmission within multiple brain regions. This paper will …

The nucleus accumbens septi (Acb) represents an interface between limbic and motor systems
and a site for modulation of these integrative functions by ascending catecholaminergic, …